{"id":"W2038206601","doi":"10.1210/endo.141.12.7856","title":"Adrenergic Regulation of Mitogen-Activated Protein Kinase in Rat Pinealocytes: Opposing Effects of Protein Kinase A and Protein Kinase G**This work was supported by grants from the Medical Research Council of Canada.","year":2000,"lang":"en","type":"article","venue":"Endocrinology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Protein kinase A; Mitogen-activated protein kinase kinase; MAP2K7; Protein kinase C; MAP kinase kinase kinase; Cyclin-dependent kinase 2; ASK1; MAPK/ERK pathway; Protein phosphorylation; Cyclin-dependent kinase 9; cGMP-dependent protein kinase; Protein kinase inhibitor; Biology; Internal medicine; Phosphorylation; Chemistry; Endocrinology; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000712779,0.0002309662,0.0004420906,0.00007264685,0.00009807591,0.000009095737,0.0003077564,0.0002679002,0.0003864185],"category_scores_gemma":[0.001007918,0.0001884971,0.00005804083,0.0003537339,0.0003540813,0.000008819922,0.0001147383,0.0003248092,5.368293e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001390726,"about_ca_system_score_gemma":0.001847341,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.08619471,"about_ca_topic_score_gemma":0.02387627,"domain_scores_codex":[0.9967021,0.0008005132,0.0006007607,0.000490967,0.0008647112,0.0005409715],"domain_scores_gemma":[0.9987045,0.0001177657,0.0002160577,0.0004395101,0.0003894583,0.0001327121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001057037,0.0001451171,0.0001326797,0.0001290314,0.00006047272,0.00006725714,0.0002019897,0.00001727018,0.9905555,0.0000537856,0.0004211559,0.007158767],"study_design_scores_gemma":[0.002033365,0.0005247496,0.0002691974,0.000497271,0.00001266778,0.000007790366,0.00007746235,0.00008916929,0.992456,0.0001225873,0.003745796,0.0001639936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994505,0.003569001,0.00004394765,0.000266924,0.00006336397,0.001426197,0.00004408147,0.000006990001,0.00007448188],"genre_scores_gemma":[0.9986148,0.0001021804,0.0002211216,0.00003021369,0.00005693529,0.000226868,0.0001098574,0.00002850789,0.0006095338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06231844,"threshold_uncertainty_score":0.9939355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01844234744721657,"score_gpt":0.2454547264643531,"score_spread":0.2270123790171365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}