{"id":"W2038206601","doi":"10.1210/endo.141.12.7856","title":"Adrenergic Regulation of Mitogen-Activated Protein Kinase in Rat Pinealocytes: Opposing Effects of Protein Kinase A and Protein Kinase G**This work was supported by grants from the Medical Research Council of Canada.","year":2000,"lang":"en","type":"article","venue":"Endocrinology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Protein kinase A; Mitogen-activated protein kinase kinase; MAP2K7; Protein kinase C; MAP kinase kinase kinase; Cyclin-dependent kinase 2; ASK1; MAPK/ERK pathway; Protein phosphorylation; Cyclin-dependent kinase 9; cGMP-dependent protein kinase; Protein kinase inhibitor; Biology; Internal medicine; Phosphorylation; Chemistry; Endocrinology; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001603764,0.0004545039,0.0002628939,0.0003624062,0.0002539033,0.0003335124,0.0001855186,0.0002659657,0.0009331036],"category_scores_gemma":[0.00008482407,0.0001810649,0.0004242799,0.0002304131,0.0002305859,0.0003019653,0.0001941308,0.0005946692,0.0003453847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000318635,"about_ca_system_score_gemma":0.0002067276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009690066,"about_ca_topic_score_gemma":0.001818953,"domain_scores_codex":[0.9998889,0.00001382133,0.00001210802,0.00002629407,0.00002397809,0.0000348507],"domain_scores_gemma":[0.9998719,0.00002082837,0.00002913855,0.00001280585,0.00001963782,0.00004579641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002194953,0.00002630508,0.0001165643,0.00003966906,0.000004460029,0.00006217194,0.00001094031,0.00001231142,0.9986117,0.00004405977,0.00001621725,0.0008361088],"study_design_scores_gemma":[0.00007571786,0.0007763498,0.05296407,0.00002711552,0.00006422404,0.0005556689,0.0001341743,0.00097604,0.9409162,0.0002056634,0.003287976,0.00001666874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750189,0.01884826,0.002203963,0.0002865406,0.000113581,0.0000485652,0.0006896046,0.00006394884,0.002726717],"genre_scores_gemma":[0.9841585,0.008413205,0.003636418,0.0001404808,0.00008450665,0.0001056263,0.0007159528,0.00002365307,0.002721691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009690066,"threshold_uncertainty_score":0.003121555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01844234744721657,"score_gpt":0.2454547264643531,"score_spread":0.2270123790171365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}