{"id":"W2038213068","doi":"10.1021/jm020235g","title":"Formaldehyde-Induced DNA Cross-Link of Indolizino[1,2-<i>b</i>]quinolines Derived from the A−D Rings of Camptothecin","year":2002,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centre in Green Chemistry and Catalysis","keywords":"Chemistry; Camptothecin; Stereochemistry; Topoisomerase; Quinoline; DNA; Ring (chemistry); Chromophore; Molecule; Biochemistry; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003069251,0.0001649519,0.0003424981,0.00002085865,0.00004247857,0.000009617966,0.0004502753,0.0001856814,0.0001794052],"category_scores_gemma":[0.0001232491,0.000113474,0.0002173941,0.00007569121,0.0001518087,0.000007030007,0.0000733963,0.0002480026,6.485179e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001862271,"about_ca_system_score_gemma":0.00009371852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003304859,"about_ca_topic_score_gemma":0.000004569906,"domain_scores_codex":[0.9986078,0.00002363437,0.0006596243,0.0001429816,0.0003725636,0.0001934588],"domain_scores_gemma":[0.9983949,0.00004627771,0.0008070173,0.0003151336,0.0003325383,0.0001041541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002417689,0.00005973035,0.0008387938,0.00005309634,0.000164676,0.000008204073,0.0002837682,0.00001051654,0.9940692,0.00000438761,0.0002574253,0.004008454],"study_design_scores_gemma":[0.001689063,0.0003387737,0.001226138,0.0001547765,0.00009024365,0.0001552999,0.0002884204,0.00003161007,0.991729,0.0001156418,0.00407187,0.0001091484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942777,0.004267979,0.0002612897,0.0004333755,0.0002226137,0.00005859124,0.00002531283,0.000002102,0.0004510882],"genre_scores_gemma":[0.9970752,0.0009970032,0.0002050788,0.0003037567,0.00126809,0.000001842571,0.000007770678,0.00001881714,0.0001224594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003899306,"threshold_uncertainty_score":0.4627337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02364905042086596,"score_gpt":0.2705705081996229,"score_spread":0.246921457778757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}