{"id":"W2038260243","doi":"10.1182/blood-2009-03-209965","title":"Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":185,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; University Health Network; Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Leukemia; Cancer research; Multiple myeloma; Pharmacology; Intracellular; Medicine; Chemistry; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001344306,0.0001169399,0.0001853402,0.00006509478,0.00003863039,0.000008618285,0.00004796615,0.0001207751,0.00001409639],"category_scores_gemma":[0.00000774692,0.00007020547,0.00002584037,0.000171522,0.00005289915,0.00003904452,0.00001264389,0.0002223266,0.000002860916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002142055,"about_ca_system_score_gemma":0.00006453605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003584944,"about_ca_topic_score_gemma":0.000007458736,"domain_scores_codex":[0.9992973,0.00002898803,0.0001860895,0.0001637896,0.0001599439,0.0001639259],"domain_scores_gemma":[0.9996608,0.00002273999,0.00008100164,0.000156392,0.00002640285,0.00005266864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000144589,0.0007211228,0.04263476,0.0001408977,0.00003603877,0.0001297042,0.00175028,0.0001098521,0.9493787,0.0001056181,0.00008536743,0.004763026],"study_design_scores_gemma":[0.005427204,0.001005936,0.4173526,0.0001737121,0.0002518047,0.00005166692,0.0006790806,0.000265428,0.574272,0.00003170496,0.0003371705,0.0001515991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945432,0.002031936,0.00001916709,0.0005416817,0.00002155263,0.0003020485,0.000001549451,0.00001449563,0.002524371],"genre_scores_gemma":[0.9988328,0.0004803849,0.0002614334,0.0001185557,0.0000308282,0.000002255865,0.000008328133,0.000009551048,0.0002559184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3751067,"threshold_uncertainty_score":0.2862896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006168829699247192,"score_gpt":0.2015109309349611,"score_spread":0.1953421012357139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}