{"id":"W2038264590","doi":"10.1158/2159-8290.cd-12-0386","title":"Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma","year":2012,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":373,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Cancer Research UK; Wellcome Trust","keywords":"Vemurafenib; Dasatinib; Cancer research; Src family kinase; Melanoma; Tyrosine kinase; EGFR inhibitors; Metastasis; Epidermal growth factor receptor; Gefitinib; Medicine; Signal transduction; Kinase; Proto-oncogene tyrosine-protein kinase Src; Biology; Cancer; Oncogene; Internal medicine; Cell cycle; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001416327,0.0003083551,0.0003192182,0.00017114,0.0001242403,0.0002268499,0.0002314895,0.0002601822,0.001309455],"category_scores_gemma":[0.00007853212,0.0000939142,0.0003435847,0.0001047215,0.0001256357,0.0001167841,0.0001344471,0.0004947482,0.0003916576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002102823,"about_ca_system_score_gemma":0.0001835464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004046576,"about_ca_topic_score_gemma":0.0007895913,"domain_scores_codex":[0.9999006,0.0000114541,0.0000107488,0.00001411772,0.0000328193,0.00003033029],"domain_scores_gemma":[0.9999553,0.000008044199,0.00001157275,0.000007441633,0.000007153677,0.00001049758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001371575,0.000112647,0.0003104896,0.00006629644,0.0000100454,0.0000719567,0.00001130162,0.0001593697,0.9920267,0.0001089926,0.0001154159,0.006869579],"study_design_scores_gemma":[0.00009007537,0.002171323,0.003855917,0.000008117049,0.00003162272,0.0009807221,0.00001526083,0.001084242,0.985254,0.00004131379,0.006461563,0.000005842707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904108,0.004181257,0.002284244,0.0001626924,0.00007424704,0.00009887524,0.0003506349,0.0001442873,0.002292963],"genre_scores_gemma":[0.9935039,0.001913088,0.002044173,0.00005393591,0.00001582323,0.00004530236,0.0005311162,0.000021003,0.001871793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001309455,"threshold_uncertainty_score":0.004380584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02031716774709106,"score_gpt":0.2606265288370754,"score_spread":0.2403093610899843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}