{"id":"W2038264590","doi":"10.1158/2159-8290.cd-12-0386","title":"Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma","year":2012,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":373,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Cancer Research UK; Wellcome Trust","keywords":"Vemurafenib; Dasatinib; Cancer research; Src family kinase; Melanoma; Tyrosine kinase; EGFR inhibitors; Metastasis; Epidermal growth factor receptor; Gefitinib; Medicine; Signal transduction; Kinase; Proto-oncogene tyrosine-protein kinase Src; Biology; Cancer; Oncogene; Internal medicine; Cell cycle; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002595705,0.0002573769,0.0002598318,0.00007003294,0.00008907971,0.00006155108,0.0001791152,0.0001873787,0.00006613028],"category_scores_gemma":[0.000103313,0.0002254572,0.0001068913,0.0001787958,0.00006801676,0.00005876386,0.0001408245,0.0001563969,0.00001896143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001032969,"about_ca_system_score_gemma":0.0002321607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000917827,"about_ca_topic_score_gemma":0.0004222788,"domain_scores_codex":[0.9983709,0.00008411908,0.0003471811,0.0004277549,0.0001860206,0.0005840473],"domain_scores_gemma":[0.9993317,0.00003689135,0.0001334766,0.0003128461,0.00004004668,0.0001450062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003980209,0.00008954854,0.03275634,0.0001039116,0.00002927694,0.00001275457,0.0002273161,0.00002028233,0.9587085,0.0002636302,0.006372783,0.001017661],"study_design_scores_gemma":[0.00114032,0.0001350782,0.008789263,0.0003406414,0.0000205195,0.000004339799,0.0005304193,0.000003086883,0.9029054,0.00004964646,0.08553758,0.0005437054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847311,0.01104988,0.0002406629,0.00009265142,0.0008911021,0.0002243018,0.0001373397,0.00002018794,0.002612828],"genre_scores_gemma":[0.9927188,0.0004758967,0.0004958298,0.0005826821,0.001759268,0.0001088822,0.0001104026,0.00004734872,0.003700891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07916479,"threshold_uncertainty_score":0.9193876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02031716774709106,"score_gpt":0.2606265288370754,"score_spread":0.2403093610899843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}