{"id":"W2038331078","doi":"10.1002/humu.21579","title":"A functional XPNPEP2 promoter haplotype leads to reduced plasma aminopeptidase P and increased risk of ACE inhibitor-induced angioedema","year":2011,"lang":"en","type":"article","venue":"Human Mutation","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal; McGill University","funders":"British Heart Foundation; CSL Behring; University of Cincinnati","keywords":"Angioedema; Hereditary angioedema; C1-inhibitor; Icatibant; Medicine; Bradykinin; Dermatology; Internal medicine; Immunology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000239324,0.0006422452,0.00031062,0.0003565027,0.0002802144,0.0002242771,0.0002051936,0.0004458041,0.003199361],"category_scores_gemma":[0.0005846393,0.0001873039,0.0003272603,0.0003306016,0.000243312,0.0001039,0.0002063062,0.000538704,0.0002751004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009246803,"about_ca_system_score_gemma":0.0001067506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006284114,"about_ca_topic_score_gemma":0.0004676883,"domain_scores_codex":[0.9997223,0.0000969955,0.0000266941,0.00008547276,0.00004031699,0.0000282824],"domain_scores_gemma":[0.9995901,0.0001478032,0.0001287784,0.00002953283,0.00002758752,0.00007613927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006715475,0.001025653,0.6352284,0.0001793177,0.0008362003,0.02469028,0.0006650083,0.0006947342,0.3137037,0.0008563176,0.001116199,0.01428871],"study_design_scores_gemma":[0.000272052,0.001175114,0.9511315,0.00004745831,0.000394145,0.03157791,0.0002052777,0.002522846,0.01068687,0.000462856,0.001496824,0.00002725497],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983299,0.000105447,0.0009506625,0.00005855036,0.00001550105,0.00001108563,0.0001702052,0.00001988765,0.0003388481],"genre_scores_gemma":[0.998844,0.00004557601,0.0004258747,0.00003142531,0.00002555232,0.00001144019,0.0001482262,0.00001117314,0.0004565972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003199361,"threshold_uncertainty_score":0.01070297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04758233086683837,"score_gpt":0.2690586970047434,"score_spread":0.221476366137905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}