{"id":"W2038338205","doi":"10.1523/jneurosci.4383-07.2007","title":"Decreased Nociceptive Sensitization in Mice Lacking the Fragile X Mental Retardation Protein: Role of mGluR1/5 and mTOR","year":2007,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":207,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; American Pain Society; FRAXA Research Foundation","keywords":"FMR1; Nociception; Metabotropic glutamate receptor; Metabotropic glutamate receptor 5; Allodynia; Metabotropic glutamate receptor 1; PI3K/AKT/mTOR pathway; Sensitization; Neuroscience; Fragile X syndrome; Glutamate receptor; Biology; Medicine; Chemistry; Hyperalgesia; Cell biology; Internal medicine; Receptor; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002998023,0.00005223507,0.00005864983,0.0000452155,0.00004672987,0.00001216256,0.00009272533,0.00002523542,9.543226e-7],"category_scores_gemma":[0.0001247694,0.00004037063,0.00002143642,0.0001174142,0.00008267431,0.00000882651,0.00004124843,0.00005778596,1.176849e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007065504,"about_ca_system_score_gemma":0.00003909354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005677509,"about_ca_topic_score_gemma":0.00002279571,"domain_scores_codex":[0.999429,0.00003542043,0.000195545,0.0001037264,0.0001449157,0.00009140297],"domain_scores_gemma":[0.9996629,0.00001088701,0.0001814009,0.00004988741,0.00006151097,0.00003334935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005251802,0.00002485196,0.004037908,0.000002861732,0.00000106326,0.0000017482,0.0001612667,0.00004959141,0.9946197,0.00000781806,0.000009373279,0.001031294],"study_design_scores_gemma":[0.00025843,0.000212086,0.2957842,0.00001541331,0.000002578475,0.00004050485,0.0003122573,0.0002684984,0.7025779,0.00004750135,0.0004332416,0.00004734355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991081,0.0001200217,0.0003302304,0.000172715,0.00006436142,0.0001013681,0.00000169223,4.82749e-7,0.0001010205],"genre_scores_gemma":[0.9993449,0.00009219965,0.0003361481,0.0001912403,0.00001291495,4.775623e-7,0.000001342339,0.000004097391,0.00001665511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2920418,"threshold_uncertainty_score":0.1646266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007980081651334545,"score_gpt":0.2351872557609464,"score_spread":0.2272071741096118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}