{"id":"W2038355080","doi":"10.1111/j.1574-6968.2001.tb10644.x","title":"Inhibition of sporulation, glycopeptide antibiotic production and resistance in Streptomyces toyocaensis NRRL 15009 by protein kinase inhibitors","year":2001,"lang":"en","type":"article","venue":"FEMS Microbiology Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"","keywords":"Glycopeptide; Glycopeptide antibiotic; Genistein; Biochemistry; Streptomyces; Streptomyces coelicolor; Antibiotics; Protein kinase A; Kinase; Phosphoprotein; Biology; Microbiology; Chemistry; Bacteria; Phosphorylation; Staphylococcus aureus; Vancomycin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001054122,0.0005250566,0.0004101791,0.0001904424,0.00009864648,0.0002562179,0.0001897022,0.0001676224,0.0006591968],"category_scores_gemma":[0.0002087947,0.0001335774,0.0002553278,0.0002157634,0.000126239,0.0001061829,0.0002009465,0.0003440806,0.0003302406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002942577,"about_ca_system_score_gemma":0.0002036466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002262845,"about_ca_topic_score_gemma":0.00225649,"domain_scores_codex":[0.9998415,0.00003253528,0.00003165736,0.00002397162,0.00004363778,0.00002670937],"domain_scores_gemma":[0.9998316,0.00003259962,0.00004572692,0.00001937437,0.00001855431,0.00005202613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001111683,0.00002572455,0.0002007176,0.00001417312,0.000003092581,0.00003134091,0.000008163337,0.00005555348,0.9989706,0.00001393267,0.00001032371,0.0005550936],"study_design_scores_gemma":[0.00002126638,0.0006390494,0.00786066,0.000005647225,0.00001404277,0.000204543,0.00004318518,0.001101459,0.9891716,0.00002508898,0.0009071626,0.000006478572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971194,0.000619934,0.0009260659,0.00004592655,0.000009498581,0.00002168622,0.0003461021,0.00004567722,0.0008656998],"genre_scores_gemma":[0.9955688,0.0003768242,0.001565506,0.00002297214,0.00000423089,0.00003111351,0.001133024,0.0000240898,0.001273287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002262845,"threshold_uncertainty_score":0.004499316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006234056624008142,"score_gpt":0.2071893118950751,"score_spread":0.200955255271067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}