{"id":"W2038374355","doi":"10.1073/pnas.0406671102","title":"Genetically stable and fully effective smallpox vaccine strain constructed from highly attenuated vaccinia LC16m8","year":2005,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Poxvirus research and outbreaks","field":"Immunology and Microbiology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Université de Lausanne","keywords":"Vaccinia; Virology; Smallpox vaccine; Modified vaccinia Ankara; Immunogenicity; Smallpox; Biology; Immunity; Virus; Strain (injury); Poxviridae; Virulence; Immune system; Vaccination; Microbiology; Immunology; Gene; Genetics; Recombinant DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007648612,0.0001132788,0.0002095153,0.0001344374,0.0002123379,0.0000202341,0.0005349485,0.0001608287,0.000175092],"category_scores_gemma":[0.0005748711,0.00007473447,0.00004420012,0.0003706908,0.0007742574,0.0002381518,0.0001922086,0.000272573,0.00001351707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002617419,"about_ca_system_score_gemma":0.00005490938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004994186,"about_ca_topic_score_gemma":0.000001275077,"domain_scores_codex":[0.9989039,0.00002666768,0.0002931668,0.0002819644,0.0002329168,0.0002613912],"domain_scores_gemma":[0.9991273,0.0003219241,0.0002171308,0.00001006214,0.0002901043,0.00003343848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001259946,0.00003639935,0.01373943,0.00001235632,0.00006712096,8.313429e-9,0.00009246216,0.000004573741,0.9749139,0.004788371,0.0009704732,0.005248887],"study_design_scores_gemma":[0.0007315153,0.0001048557,0.4100473,0.0000351176,0.00001533524,0.00001080945,0.00008513572,0.00008706038,0.5820889,0.005863622,0.0008563465,0.00007398949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931751,0.0008708799,9.302568e-7,0.003477155,0.00001659638,0.0002594075,0.0002107466,0.0000153753,0.001973823],"genre_scores_gemma":[0.9987625,0.00005542081,0.0007334664,0.0002142678,0.00004225871,0.000009939269,0.000001934393,0.000003803212,0.0001764312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3963078,"threshold_uncertainty_score":0.3047583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01809860594258242,"score_gpt":0.2782759942457513,"score_spread":0.2601773883031688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}