{"id":"W2038437324","doi":"10.4161/chan.24905","title":"In silico assessment of drug safety in human heart applied to late sodium current blockers","year":2013,"lang":"en","type":"article","venue":"Channels","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bible College; University of Calgary","funders":"","keywords":"Sodium channel; Ranolazine; Repolarization; Pharmacology; In silico; Drug; QT interval; Safety pharmacology; Proarrhythmia; Biomarker; Medicine; Anti-Arrhythmia Agents; Sodium channel blocker; Potassium channel blocker; Cardiology; Chemistry; Internal medicine; Electrophysiology; Potassium channel; Sodium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001892086,0.000125398,0.000434512,0.0001819472,0.00002702565,0.000003882025,0.00005161109,0.00005885916,0.0001429065],"category_scores_gemma":[0.00001036899,0.0001143818,0.00007790078,0.0002337711,0.00004366348,0.0000362928,0.00005295185,0.0002778902,0.00006079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009557646,"about_ca_system_score_gemma":0.00005734632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001498958,"about_ca_topic_score_gemma":0.00001668191,"domain_scores_codex":[0.9989968,0.00004214203,0.0002985422,0.0002433566,0.0001190688,0.000300103],"domain_scores_gemma":[0.9995762,0.00003724193,0.00004216836,0.0002141531,0.0000337157,0.00009655263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003255768,0.0008193631,0.01453078,0.0003450486,0.00007774612,0.00006205742,0.004191895,0.002992576,0.9567591,0.001976934,0.01440234,0.003516599],"study_design_scores_gemma":[0.006648426,0.0006243821,0.843998,0.0005449482,0.00005321404,0.00002527828,0.0006040069,0.001033323,0.137516,0.003689458,0.004643016,0.00061991],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947804,0.00008750748,0.0000111157,0.002873262,0.0002383561,0.0007902965,0.000002594471,0.00001587994,0.001200647],"genre_scores_gemma":[0.9987095,0.00001878491,0.00008502639,0.0004804245,0.0001871409,0.0001361693,0.00001549228,0.00001269841,0.000354776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8294672,"threshold_uncertainty_score":0.4664356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0108761843022771,"score_gpt":0.3018477457675517,"score_spread":0.2909715614652746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}