{"id":"W2038437324","doi":"10.4161/chan.24905","title":"In silico assessment of drug safety in human heart applied to late sodium current blockers","year":2013,"lang":"en","type":"article","venue":"Channels","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bible College; University of Calgary","funders":"","keywords":"Sodium channel; Ranolazine; Repolarization; Pharmacology; In silico; Drug; QT interval; Safety pharmacology; Proarrhythmia; Biomarker; Medicine; Anti-Arrhythmia Agents; Sodium channel blocker; Potassium channel blocker; Cardiology; Chemistry; Internal medicine; Electrophysiology; Potassium channel; Sodium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004630514,0.0005571253,0.0009570514,0.0003834118,0.0002917362,0.0006384912,0.0007377501,0.001446497,0.002355876],"category_scores_gemma":[0.001828602,0.0004339087,0.0009632587,0.0002869649,0.0003843527,0.0003038319,0.0005100714,0.0005755317,0.0002310469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004934561,"about_ca_system_score_gemma":0.000895341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007621528,"about_ca_topic_score_gemma":0.004935123,"domain_scores_codex":[0.9998604,0.00005132223,0.000008607353,0.000021484,0.00003190364,0.00002627465],"domain_scores_gemma":[0.998596,0.001144586,0.00007632514,0.0000385004,0.0001043809,0.00004020649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00005984058,0.00002513281,0.0008615293,0.0000619097,0.00002085736,0.00005463834,0.00001085014,0.9966078,0.001026668,0.0004025618,0.0001116661,0.0007564919],"study_design_scores_gemma":[0.00002832096,0.0000597002,0.0003005119,0.000008137207,0.00001805471,0.00001465299,0.000009522028,0.9982033,0.0007827872,0.0003246564,0.0002457603,0.000004541585],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9299257,0.0008459139,0.05278442,0.0005902466,0.0001058514,0.0001479983,0.002328684,0.0003152312,0.01295592],"genre_scores_gemma":[0.9841099,0.0003634783,0.01245641,0.0001688861,0.00001800926,0.0001931794,0.0009001176,0.00004200738,0.001747892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007621528,"threshold_uncertainty_score":0.0151543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0108761843022771,"score_gpt":0.3018477457675517,"score_spread":0.2909715614652746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}