{"id":"W2038445357","doi":"10.1186/1745-6215-13-173","title":"A theoretical framework for early human studies: uncertainty, intervention ensembles, and boundaries","year":2012,"lang":"en","type":"review","venue":"Trials","topic":"Meta-analysis and systematic reviews","field":"Decision Sciences","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Intervention (counseling); Psychological intervention; Set (abstract data type); Outcome (game theory); Dimension (graph theory); Negotiation; Clinical trial; Medicine; Management science; Computer science; Sociology; Mathematics; Social science; Nursing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.5009784,0.004410867,0.00748302,0.009352616,0.006513933,0.01361157,0.009994765,0.0146167,0.006345256],"category_scores_gemma":[0.5010018,0.00320349,0.004991102,0.005142399,0.08048315,0.02508899,0.01528924,0.01485916,0.0008386824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01420413,"about_ca_system_score_gemma":0.01731713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002987025,"about_ca_topic_score_gemma":0.002043517,"domain_scores_codex":[0.401867,0.5473262,0.01118549,0.01672353,0.02039259,0.002505105],"domain_scores_gemma":[0.2228275,0.7188001,0.01904342,0.02764335,0.009380249,0.002305453],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001071748,0.00004402643,0.0004018075,0.0007371602,0.0002214974,0.00007618628,0.001640182,0.00291966,0.00006597405,0.98437,0.0007497287,0.008666574],"study_design_scores_gemma":[0.0001498106,0.000143417,0.0001043906,0.0005001218,0.00006378019,0.00005818006,0.0001820078,0.002633936,0.0001161061,0.9909173,0.005097867,0.00003306592],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.004191707,0.008453043,0.9303227,0.03359605,0.0007308681,0.003280843,0.0002687624,0.0001127953,0.01904323],"genre_scores_gemma":[0.1521716,0.003384246,0.8043616,0.01340284,0.001117395,0.02414731,0.0001622218,0.00008324502,0.001169489],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.4990216,"threshold_uncertainty_score":0.6153826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.945042611472735,"score_gpt":0.6964557917395531,"score_spread":0.248586819733182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}