{"id":"W2038472314","doi":"10.1016/s0140-6736(14)60417-7","title":"Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial","year":2014,"lang":"en","type":"article","venue":"The Lancet","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":155,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Agency for Healthcare Research and Quality; National Institutes of Health; Duke Clinical Research Institute; King's College London; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Guy's and St Thomas' NHS Foundation Trust; Abbott Vascular; GlaxoSmithKline; AstraZeneca","keywords":"Medicine; Myocardial infarction; Placebo; Internal medicine; Adverse effect; Cardiology; Gastroenterology; ST segment; Heart failure; Natriuretic peptide; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000640383,0.0001756737,0.0003163028,0.000042202,0.00007764422,0.00003324271,0.0001990848,0.0001430568,0.00001704298],"category_scores_gemma":[0.0001732524,0.0001326185,0.0001028233,0.0001176265,0.00004653325,0.000006575188,0.0000651615,0.000146444,0.00001231462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003204814,"about_ca_system_score_gemma":0.0001011917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005237521,"about_ca_topic_score_gemma":0.00003029596,"domain_scores_codex":[0.9988013,0.0001668366,0.0002843995,0.000300339,0.0001645685,0.0002825834],"domain_scores_gemma":[0.9992492,0.00002123445,0.000132469,0.0004870933,0.00005170255,0.00005825443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.06545448,0.0001915113,0.00007448263,0.00001521108,0.00003955257,8.682729e-7,0.000123895,0.00002303753,0.930409,0.00004319728,0.001595056,0.002029712],"study_design_scores_gemma":[0.3012351,0.0009686897,0.0003448857,0.00003050885,0.0000204966,0.000004036665,0.00002454194,0.000278007,0.6463267,0.00007340766,0.05047877,0.0002148563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919528,0.0000398179,0.004713371,0.0005255646,0.0005482022,0.001552494,0.00004362934,0.00001910731,0.0006050471],"genre_scores_gemma":[0.9946067,0.00001197119,0.0002837001,0.0003729898,0.00379997,0.0004815288,0.0002338394,0.00002001988,0.0001893216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2840823,"threshold_uncertainty_score":0.5408027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01941750322966135,"score_gpt":0.261405493622285,"score_spread":0.2419879903926237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}