{"id":"W2038487059","doi":"10.1073/pnas.1300886110","title":"Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":324,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Medical Research Council; Regione Lombardia; Ministero della Salute; Canada Research Chairs; Servier; European Commission; Research Councils UK; National Alliance for Research on Schizophrenia and Depression; Eli Lilly and Company","keywords":"SGK1; Neurogenesis; Glucocorticoid receptor; Glucocorticoid; Hippocampal formation; Endocrinology; Internal medicine; Corticosterone; Biology; Medicine; Cell biology; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009227319,0.0005416996,0.0002554459,0.0001784698,0.0002287203,0.0002928123,0.0001377377,0.0002206718,0.0007181772],"category_scores_gemma":[0.00007908983,0.00009780088,0.0002274568,0.0001028589,0.0003557941,0.0001394983,0.0002067124,0.0004856676,0.0002558237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005341244,"about_ca_system_score_gemma":0.0002642641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006357832,"about_ca_topic_score_gemma":0.001218675,"domain_scores_codex":[0.9999578,0.000007126117,0.000003709699,0.00001096831,0.000008687231,0.00001166898],"domain_scores_gemma":[0.9999599,0.000005226862,0.00001474614,0.00000259517,0.000003542667,0.00001390506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00148643,0.0001201392,0.002610997,0.0005669019,0.00006686629,0.0006384779,0.00007138675,0.000512043,0.9593579,0.0008782341,0.0005679276,0.03312266],"study_design_scores_gemma":[0.0003040154,0.001751991,0.2008744,0.0001240565,0.0002517323,0.00271859,0.0002579306,0.002543601,0.7683234,0.00177863,0.02102166,0.00005011547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9308492,0.06111348,0.002010033,0.0009575348,0.0001337305,0.00003724619,0.0003855211,0.0001169382,0.004396353],"genre_scores_gemma":[0.9800833,0.01671817,0.0009172044,0.0001496228,0.00003269769,0.00002719429,0.0003425207,0.00000667189,0.00172246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007181772,"threshold_uncertainty_score":0.003875315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02975518043797453,"score_gpt":0.2749428014024271,"score_spread":0.2451876209644525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}