{"id":"W2038494864","doi":"10.1016/j.clinthera.2005.07.010","title":"Antihypertensive Efficacy and Tolerability of Two Fixed-Dose Combinations of Valsartan and Hydrochlorothiazide Compared with Valsartan Monotherapy in Patients with Stage 2 or 3 Systolic Hypertension: An 8-Week, Randomized, Double-Blind, Parallel-Group Trial","year":2005,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Blood Pressure and Hypertension Studies","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"Novartis (Canada); Université Laval; Centre hospitalier de l'Université Laval","funders":"","keywords":"Valsartan; Medicine; Tolerability; Hydrochlorothiazide; Blood pressure; Combination therapy; Diuretic; Urology; Placebo; Internal medicine; Population; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001107313,0.0003869577,0.003489168,0.0001513293,0.0001128157,0.00002287439,0.000130394,0.0001816239,0.00001413984],"category_scores_gemma":[0.0001195725,0.0002206178,0.0001468463,0.0002810821,0.001221468,0.0001630075,0.00005970726,0.0004111226,8.530773e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001175112,"about_ca_system_score_gemma":0.00009884426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001039768,"about_ca_topic_score_gemma":0.0002773335,"domain_scores_codex":[0.9964505,0.0005649768,0.001599364,0.0005968368,0.0004884297,0.0002998775],"domain_scores_gemma":[0.9956006,0.002187495,0.00059946,0.0006494673,0.0007506566,0.0002123153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9243891,0.01063781,0.05907146,0.00009702853,0.001563295,0.00001571567,0.0007440801,0.00005309578,0.0000800855,0.0002180879,0.00001407102,0.003116179],"study_design_scores_gemma":[0.9211527,0.006854231,0.06678814,0.000297231,0.002067337,0.00001714111,0.0002598283,0.001676122,0.00009787617,0.00006053199,0.0004356,0.0002932797],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928449,0.0022324,0.00008398437,0.0008833748,0.00008271381,0.003763526,0.00002041527,0.00003594013,0.00005276251],"genre_scores_gemma":[0.9943998,0.001097644,0.002356837,0.00185887,0.00009710299,0.00006447163,0.00003167163,0.00004585926,0.0000477739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00771667,"threshold_uncertainty_score":0.8996533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1536595223732577,"score_gpt":0.3880872117955314,"score_spread":0.2344276894222736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}