{"id":"W2038494864","doi":"10.1016/j.clinthera.2005.07.010","title":"Antihypertensive Efficacy and Tolerability of Two Fixed-Dose Combinations of Valsartan and Hydrochlorothiazide Compared with Valsartan Monotherapy in Patients with Stage 2 or 3 Systolic Hypertension: An 8-Week, Randomized, Double-Blind, Parallel-Group Trial","year":2005,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Blood Pressure and Hypertension Studies","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"Novartis (Canada); Université Laval; Centre hospitalier de l'Université Laval","funders":"","keywords":"Valsartan; Medicine; Tolerability; Hydrochlorothiazide; Blood pressure; Combination therapy; Diuretic; Urology; Placebo; Internal medicine; Population; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00262531,0.003213361,0.007427673,0.0009186224,0.0008315235,0.00141728,0.001954475,0.003090868,0.005178966],"category_scores_gemma":[0.002830701,0.001967296,0.003190805,0.0007401423,0.002336148,0.002335786,0.0006132678,0.005005084,0.001126183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009633811,"about_ca_system_score_gemma":0.001060745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001045549,"about_ca_topic_score_gemma":0.001809372,"domain_scores_codex":[0.9984078,0.0007980845,0.0001196461,0.0003163035,0.0001260977,0.0002321952],"domain_scores_gemma":[0.997683,0.0007062851,0.0004474875,0.0002742486,0.0001262743,0.0007625275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9890738,0.005315398,0.0003030123,0.0001116184,0.0005387746,0.00001580429,0.00002901558,0.0001266389,0.001210717,0.00001835529,0.0001059255,0.003151065],"study_design_scores_gemma":[0.9361078,0.06176759,0.001154885,0.000006182324,0.0003662668,0.00001259989,0.00001233563,0.0002035814,0.000254,0.00003532144,0.0000635621,0.00001589447],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963195,0.001226925,0.0003266522,0.0002332833,0.0002761316,0.000606993,0.000398198,0.00007575934,0.0005364956],"genre_scores_gemma":[0.9934939,0.0009878142,0.001104408,0.0005436729,0.0006339544,0.001226321,0.0006323112,0.00003065122,0.001347087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007427673,"threshold_uncertainty_score":0.01732534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1536595223732577,"score_gpt":0.3880872117955314,"score_spread":0.2344276894222736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}