{"id":"W2038509173","doi":"10.1016/j.immuni.2011.09.013","title":"T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex","year":2011,"lang":"en","type":"article","venue":"Immunity","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":263,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Canadian Institutes of Health Research; Howard Hughes Medical Institute; National Institutes of Health; National Science Foundation","keywords":"T-cell receptor; Major histocompatibility complex; Biology; Cell biology; Signal transduction; Docking (animal); Computational biology; Receptor; Peptide; T cell; Antigen; Immunology; Immune system; Genetics; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0006218812,0.0004346407,0.0006338284,0.0002603801,0.0007319379,0.00002536203,0.0009507056,0.0004821729,0.01444203],"category_scores_gemma":[0.0001199514,0.0004245267,0.0002200809,0.0004728876,0.0004032583,0.0001465334,0.0004932609,0.0009872086,0.004973232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001724408,"about_ca_system_score_gemma":0.00006541255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004569996,"about_ca_topic_score_gemma":0.00005235368,"domain_scores_codex":[0.9970633,0.0007073231,0.0007091755,0.0006043245,0.00006939573,0.0008464626],"domain_scores_gemma":[0.9980026,0.0002983596,0.000276095,0.001129314,0.0002086637,0.00008492108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003310255,0.0008340817,0.003686541,0.00003150813,0.0001422853,0.000002122714,0.003317289,0.000001478156,0.9316131,0.00002347448,0.05880008,0.001216954],"study_design_scores_gemma":[0.001356472,0.0004723185,0.003474954,0.00002956023,0.00005664832,0.0000139403,0.0008384183,0.000003023511,0.8719672,0.0000827786,0.1212,0.0005047129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892009,0.002021765,0.0002643587,0.0001512566,0.0008830049,0.0005849844,0.0001601525,0.0002687408,0.006464875],"genre_scores_gemma":[0.9924956,0.00002353262,0.0009419694,0.001017316,0.00002732726,0.00004770107,0.0004022635,0.00004546568,0.004998832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06239987,"threshold_uncertainty_score":0.9998206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04100093633211564,"score_gpt":0.2453777477867785,"score_spread":0.2043768114546628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}