{"id":"W2038579629","doi":"10.1021/jm1000437","title":"Antibacterial Activities of Aminoglycoside Antibiotics-Derived Cationic Amphiphiles. Polyol-Modified Neomycin B-, Kanamycin A-, Amikacin-, and Neamine-Based Amphiphiles with Potent Broad Spectrum Antibacterial Activity","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Antimicrobial agents and applications","field":"Chemistry","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Manitoba Health Research Council","keywords":"Aminoglycoside; Neomycin; Chemistry; Antibacterial activity; Polyol; Amphiphile; Kanamycin; Amikacin; Antibiotics; Antibacterial agent; Stereochemistry; Biochemistry; Bacteria; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002937619,0.0004675786,0.0008714153,0.0001178197,0.0002060013,0.00009873132,0.000458499,0.0003324087,0.0003973414],"category_scores_gemma":[0.0001061879,0.0003812919,0.0002002082,0.0001944712,0.0008506068,0.0002508887,0.00008247144,0.0009477936,0.000001078461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000933499,"about_ca_system_score_gemma":0.000544525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001782886,"about_ca_topic_score_gemma":0.00005221017,"domain_scores_codex":[0.9976263,0.0000308803,0.000848579,0.0004219586,0.0006160166,0.0004562717],"domain_scores_gemma":[0.9972398,0.0001660062,0.001518777,0.0005088424,0.0002258726,0.0003406568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001278669,0.0004752911,0.003997702,0.0004218485,0.0001691032,0.00005697908,0.000131705,0.00001989783,0.9914801,0.00002279498,0.00008832203,0.001857613],"study_design_scores_gemma":[0.003426775,0.000168701,0.01778318,0.0004604245,0.0002934945,0.000534851,0.0002286608,0.0001056299,0.9763517,0.00004177302,0.0002239265,0.0003809092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969518,0.00005628292,0.0005932004,0.001280945,0.0002594766,0.0001271438,0.000133584,0.0000332987,0.0005642751],"genre_scores_gemma":[0.9972737,0.0001183983,0.000652703,0.00005952008,0.001647625,0.000001369747,0.00006091808,0.00005424575,0.0001314721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0151284,"threshold_uncertainty_score":0.9998639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006994179648102302,"score_gpt":0.218570167475528,"score_spread":0.2115759878274257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}