{"id":"W2038579629","doi":"10.1021/jm1000437","title":"Antibacterial Activities of Aminoglycoside Antibiotics-Derived Cationic Amphiphiles. Polyol-Modified Neomycin B-, Kanamycin A-, Amikacin-, and Neamine-Based Amphiphiles with Potent Broad Spectrum Antibacterial Activity","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Antimicrobial agents and applications","field":"Chemistry","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Manitoba Health Research Council","keywords":"Aminoglycoside; Neomycin; Chemistry; Antibacterial activity; Polyol; Amphiphile; Kanamycin; Amikacin; Antibiotics; Antibacterial agent; Stereochemistry; Biochemistry; Bacteria; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001776116,0.000317569,0.0001634818,0.000155592,0.00007623176,0.0001507765,0.00008727808,0.0002601524,0.0003358673],"category_scores_gemma":[0.0002294632,0.00009467435,0.0001369994,0.00008415109,0.0001591673,0.0001524877,0.0001879241,0.0002672837,0.00011319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001039022,"about_ca_system_score_gemma":0.00009938379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001501705,"about_ca_topic_score_gemma":0.0002379956,"domain_scores_codex":[0.9998844,0.00003210613,0.00001166784,0.00001405694,0.00003556622,0.00002229486],"domain_scores_gemma":[0.9998773,0.00003367109,0.00003018177,0.000008181935,0.00001805725,0.00003261112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005992148,0.00001323322,0.00007836498,0.00002809878,0.000002427934,0.00001879257,0.00000714935,0.0000399491,0.9987217,0.00001951768,0.000007197641,0.001003705],"study_design_scores_gemma":[0.00001003771,0.0004008195,0.001707511,0.000005193421,0.00001057464,0.0001493479,0.000006348941,0.0002861394,0.9968157,0.000008697751,0.0005961674,0.000003454797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968297,0.001781506,0.0006569551,0.0000301599,0.000008537087,0.00001461409,0.00006037814,0.00001059117,0.0006074746],"genre_scores_gemma":[0.9968707,0.001040134,0.00150031,0.00002446223,0.000007336781,0.00002212332,0.0001501089,0.000004246588,0.0003806254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003358673,"threshold_uncertainty_score":0.001123607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006994179648102302,"score_gpt":0.218570167475528,"score_spread":0.2115759878274257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}