{"id":"W2038595841","doi":"10.1016/j.bmcl.2015.02.032","title":"Tandem DNAzymes for mRNA cleavage: Choice of enzyme, metal ions and the antisense effect","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; University of Waterloo","keywords":"Deoxyribozyme; Chemistry; Tandem; Cleavage (geology); Enzyme; Messenger RNA; Metal ions in aqueous solution; Stereochemistry; Ion; Biophysics; Biochemistry; DNA; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007045134,0.0004644361,0.0004919384,0.000168511,0.0001550084,0.0005556084,0.0003955956,0.0007064477,0.0008539651],"category_scores_gemma":[0.0009049325,0.0003446177,0.0003115652,0.0002119288,0.0003536333,0.0004931812,0.0003205249,0.0008230073,0.0005103627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003612765,"about_ca_system_score_gemma":0.0002734037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002303964,"about_ca_topic_score_gemma":0.0005796338,"domain_scores_codex":[0.999584,0.00006575554,0.00004387664,0.0001478169,0.0001003718,0.00005818983],"domain_scores_gemma":[0.9995757,0.0001686887,0.00009172795,0.00004376607,0.00006195292,0.00005810854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007356534,0.000009905802,0.00004399189,0.00001747822,0.00000281979,0.00001721808,0.000008752408,0.00006080111,0.9983196,0.0001716438,0.0000142058,0.00125997],"study_design_scores_gemma":[0.000007456778,0.00008941629,0.00007200427,0.000001446808,0.000006423542,0.00008185948,0.000003541873,0.0003415094,0.9989638,0.00004448043,0.0003841248,0.000003870323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9349763,0.003253796,0.05838452,0.0003511533,0.0001006304,0.00009109053,0.0001653668,0.0002986342,0.002378464],"genre_scores_gemma":[0.9620603,0.001210982,0.03322417,0.0001238707,0.00002844267,0.00006999998,0.0001622655,0.00007545005,0.003044621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008539651,"threshold_uncertainty_score":0.003725886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01299233455448376,"score_gpt":0.2730601240224382,"score_spread":0.2600677894679545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}