{"id":"W2038625629","doi":"10.1016/j.chembiol.2008.01.001","title":"Defining the Defect in F508 del CFTR: A Soluble Problem?","year":2008,"lang":"en","type":"letter","venue":"Chemistry & Biology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"ΔF508; Biology; Mutation; Genetics; Cystic fibrosis transmembrane conductance regulator; Molecular biology; Cystic fibrosis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003471964,0.001228997,0.002825617,0.0007430122,0.002431554,0.00287607,0.00225105,0.05121929,0.003449221],"category_scores_gemma":[0.01953823,0.0007230875,0.001142435,0.0005045131,0.005352329,0.007386228,0.002482892,0.04520728,0.003179384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003228571,"about_ca_system_score_gemma":0.001667254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001645736,"about_ca_topic_score_gemma":0.00227458,"domain_scores_codex":[0.9974384,0.0008234777,0.0004728381,0.0003620288,0.0005991785,0.0003039566],"domain_scores_gemma":[0.9926643,0.004667798,0.000424024,0.0002227485,0.0009470193,0.001074125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001609141,0.0001030835,0.001054039,0.0001648067,0.00002818754,0.009288011,0.000246125,0.0001380826,0.0006420017,0.01557413,0.9409317,0.03166908],"study_design_scores_gemma":[0.0004720046,0.0003115664,0.001767176,0.0006983634,0.00008974597,0.02704041,0.001330238,0.001403419,0.0009084167,0.112056,0.8537723,0.0001502739],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0005152759,0.003018635,0.0003743269,0.9841275,0.01081122,0.000005957736,0.00002001136,0.00001808178,0.001109096],"genre_scores_gemma":[0.007545692,0.004596436,0.0009655184,0.8955824,0.08860724,0.00002535175,0.00003713167,0.00002491433,0.002615264],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.05121929,"threshold_uncertainty_score":0.02342504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01603654439282846,"score_gpt":0.2966801935070709,"score_spread":0.2806436491142424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}