{"id":"W2038642995","doi":"10.1002/eji.200737902","title":"Interleukin‐10‐induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes","year":2008,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Sherbrooke; Université de Montréal","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Liver Foundation; Canadian Institutes of Health Research; Institut National de la Santé et de la Recherche Médicale; National Cancer Institute; National Institutes of Health","keywords":"MHC class II; Biology; Antigen presentation; MHC class I; Antigen processing; Ubiquitin ligase; Transfection; Molecular biology; Major histocompatibility complex; Cell biology; Ubiquitin; Antigen; Immune system; T cell; Immunology; Cell culture; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001348368,0.0002554966,0.0006416292,0.0006038191,0.0001611617,0.000007379662,0.0006393285,0.000175233,0.0006226155],"category_scores_gemma":[0.0004006145,0.0002216337,0.0002104211,0.0002373998,0.0005976189,0.0002560957,0.0001461099,0.0008604333,0.0001733273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000079055,"about_ca_system_score_gemma":0.0002127619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003006631,"about_ca_topic_score_gemma":0.000003466749,"domain_scores_codex":[0.9955474,0.0024182,0.001381241,0.0001913565,0.00006580541,0.0003960461],"domain_scores_gemma":[0.9981685,0.0003071583,0.0009249452,0.0003333311,0.000246237,0.00001984693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003021657,0.0002962209,0.0006190375,0.00000947413,0.000396447,0.0002666457,0.002984572,0.00001202784,0.980183,0.0001613124,0.0004327272,0.01161686],"study_design_scores_gemma":[0.004343751,0.00464675,0.05038106,0.0001679534,0.00003308189,0.002676577,0.0007007265,0.000002576439,0.9157644,0.00006479934,0.02097594,0.0002424074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763068,0.02119105,0.0000659561,0.0004036524,0.0009423989,0.0001167412,0.000004174673,0.0000204206,0.0009488244],"genre_scores_gemma":[0.9956018,0.002933027,0.0001738853,0.00006023828,0.00005244869,0.000001697015,0.00001747835,0.00003753113,0.001121915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06441865,"threshold_uncertainty_score":0.903796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02406831464142862,"score_gpt":0.2332397851355068,"score_spread":0.2091714704940782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}