{"id":"W2038660811","doi":"10.1089/oli.2009.0180","title":"siRNA and Innate Immunity","year":2009,"lang":"en","type":"review","venue":"Oligonucleotides","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":459,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"","keywords":"Innate immune system; Small interfering RNA; Biology; Cell biology; RNA interference; Immune system; Immunity; Intracellular; Signal transduction; RNA; Immunology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003390283,0.0008302619,0.0008761161,0.0009000722,0.0002665333,0.0008316727,0.0006548854,0.001052011,0.003120808],"category_scores_gemma":[0.0002667865,0.0002193159,0.0002484418,0.001018607,0.0005750462,0.0009991631,0.0005366983,0.001370137,0.003584474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006652815,"about_ca_system_score_gemma":0.000694327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004017255,"about_ca_topic_score_gemma":0.000750196,"domain_scores_codex":[0.9998037,0.00003482807,0.00002246352,0.0000395343,0.00008184241,0.00001770332],"domain_scores_gemma":[0.9998777,0.00004721362,0.00001691237,0.000007019586,0.00003629732,0.00001472906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008067948,0.00006057604,0.0001408046,0.005971936,0.00004081768,0.000353006,0.0000898746,0.0003886141,0.03795432,0.01106828,0.02110294,0.9227482],"study_design_scores_gemma":[0.00001416041,0.00008794123,0.0004684269,0.0005256178,0.00002200051,0.001274227,0.00003678301,0.0001014775,0.007636299,0.003890108,0.985929,0.00001393225],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005608728,0.9914758,0.001153704,0.0004283498,0.0005475561,0.00001287186,0.00002408762,0.00003111888,0.005765706],"genre_scores_gemma":[0.003902045,0.9859666,0.001387327,0.0006893945,0.0003653262,0.0000395559,0.00008331144,0.000006406766,0.007559981],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003120808,"threshold_uncertainty_score":0.01044017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02866954832787951,"score_gpt":0.3075945759187574,"score_spread":0.2789250275908779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}