{"id":"W2038660811","doi":"10.1089/oli.2009.0180","title":"siRNA and Innate Immunity","year":2009,"lang":"en","type":"review","venue":"Oligonucleotides","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":459,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"","keywords":"Innate immune system; Small interfering RNA; Biology; Cell biology; RNA interference; Immune system; Immunity; Intracellular; Signal transduction; RNA; Immunology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001352682,0.0003418996,0.0006445859,0.00007818187,0.00008295122,0.00006116266,0.0003107447,0.0003175433,0.00002560602],"category_scores_gemma":[0.00004953043,0.0002847975,0.0002484432,0.00008001769,0.00008638158,0.00000363201,0.0002014005,0.000211413,0.00009307171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001043077,"about_ca_system_score_gemma":0.00008195426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002031668,"about_ca_topic_score_gemma":0.000009093897,"domain_scores_codex":[0.99889,0.00009778597,0.0003056923,0.0003891843,0.00007224683,0.0002451293],"domain_scores_gemma":[0.9992403,0.00001380156,0.0001495728,0.0004699714,0.00004118235,0.00008514465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005394625,0.00002075168,0.000003370858,0.000791777,0.0001010363,0.00000670813,0.000007942075,1.548198e-7,0.0003081341,0.00002555166,0.002881114,0.9958481],"study_design_scores_gemma":[0.00006967464,0.0001811886,0.00002670533,0.001310122,0.0001512137,0.00006742495,0.000008362371,5.139749e-7,0.0003229159,0.00004087007,0.9974976,0.0003234471],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002278866,0.9938447,0.000005746797,0.00001122773,0.0001239496,0.0001862431,0.00002775052,0.00001644854,0.003505014],"genre_scores_gemma":[0.0006885307,0.9970515,0.0001283452,0.0001514871,0.0002479244,0.00001313721,0.0001978261,0.00003631589,0.00148491],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9955246,"threshold_uncertainty_score":0.9999604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02866954832787951,"score_gpt":0.3075945759187574,"score_spread":0.2789250275908779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}