{"id":"W2038698150","doi":"10.1074/jbc.m403242200","title":"Roles of Conserved P Domain Residues and Mg2+ in ATP Binding in the Ground and Ca2+-activated States of Sarcoplasmic Reticulum Ca2+-ATPase","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Novo Nordisk Fonden; H. Lundbeck A/S; Lundbeckfonden; University of Cape Town; National Research Foundation; Medical Research Council; Aarhus Universitet; Novo Nordisk; Sundhed og Sygdom, Det Frie Forskningsråd","keywords":"Endoplasmic reticulum; Nucleotide; Mutant; Binding site; ATPase; Mutagenesis; Chemistry; Cyclic nucleotide-binding domain; Phosphorylation; Affinities; Adenosine triphosphate; Binding domain; Biophysics; Biochemistry; Stereochemistry; Crystallography; Biology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003576588,0.00009956317,0.000217402,0.00003098748,0.00001912567,0.000006168666,0.00008968054,0.0001758642,0.000004798147],"category_scores_gemma":[0.00005884501,0.0000633172,0.00004734271,0.00008976109,0.0002226728,0.000005850512,0.00002129381,0.0001279665,2.772811e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001350285,"about_ca_system_score_gemma":0.00003633598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003165295,"about_ca_topic_score_gemma":0.00003985724,"domain_scores_codex":[0.9992284,0.00004540875,0.0004008214,0.0001205335,0.00008981084,0.0001150629],"domain_scores_gemma":[0.9995441,0.00003780367,0.0002510447,0.00007483764,0.00005712484,0.00003512961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003714086,0.00007579935,0.04798426,0.00005479131,0.00001641136,0.00002594003,0.0002645154,0.00006393922,0.9510655,0.000009453205,0.000004806001,0.00006317558],"study_design_scores_gemma":[0.001168926,0.0002526235,0.05865945,0.0001182328,0.000008152455,0.0001079593,0.001983506,0.000002688346,0.9369296,0.0006153981,0.00007750855,0.00007598432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984888,0.001095773,0.00002343737,0.0002877986,0.00001064783,0.00005448241,0.00001228933,0.000001105141,0.00002565309],"genre_scores_gemma":[0.9986874,0.001046745,0.0001654463,0.00002284665,0.0000333477,0.000001342127,0.00003341926,0.000004059762,0.000005413122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01413593,"threshold_uncertainty_score":0.2582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277933813184442,"score_gpt":0.2330478864059093,"score_spread":0.2202685482740649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}