{"id":"W2038698150","doi":"10.1074/jbc.m403242200","title":"Roles of Conserved P Domain Residues and Mg2+ in ATP Binding in the Ground and Ca2+-activated States of Sarcoplasmic Reticulum Ca2+-ATPase","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Novo Nordisk Fonden; H. Lundbeck A/S; Lundbeckfonden; University of Cape Town; National Research Foundation; Medical Research Council; Aarhus Universitet; Novo Nordisk; Sundhed og Sygdom, Det Frie Forskningsråd","keywords":"Endoplasmic reticulum; Nucleotide; Mutant; Binding site; ATPase; Mutagenesis; Chemistry; Cyclic nucleotide-binding domain; Phosphorylation; Affinities; Adenosine triphosphate; Binding domain; Biophysics; Biochemistry; Stereochemistry; Crystallography; Biology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001580171,0.0002804296,0.0001727787,0.00009374777,0.0001947778,0.0002448157,0.0002548929,0.0002757754,0.0007915613],"category_scores_gemma":[0.0002546905,0.0001487765,0.0001802168,0.0001025651,0.0003095212,0.0002270208,0.0002023469,0.0002322639,0.0002732328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002089478,"about_ca_system_score_gemma":0.0002475966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006025701,"about_ca_topic_score_gemma":0.0007102232,"domain_scores_codex":[0.9999043,0.0000250824,0.000007622798,0.00001884395,0.00002307158,0.00002103817],"domain_scores_gemma":[0.9998752,0.00004217054,0.00002727231,0.000008813247,0.00001022114,0.00003629152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006569372,0.00007188297,0.001270231,0.00003744513,0.000009926288,0.0003910608,0.00005360117,0.0007384929,0.9935615,0.0002936551,0.00002677027,0.002888543],"study_design_scores_gemma":[0.0001584967,0.000867829,0.01378304,0.00001700138,0.00003889929,0.0009013453,0.000124367,0.005761018,0.9768331,0.0003134196,0.001178539,0.00002297588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985099,0.00012036,0.0008448489,0.00001727757,0.000002837994,0.000008264412,0.00001786488,0.00001432349,0.0004641731],"genre_scores_gemma":[0.9993083,0.00004472256,0.0003896923,0.0000111251,8.804535e-7,0.0000040272,0.00003306367,0.000004451425,0.0002037277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007915613,"threshold_uncertainty_score":0.002647996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277933813184442,"score_gpt":0.2330478864059093,"score_spread":0.2202685482740649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}