{"id":"W2038715330","doi":"10.1016/j.neuroscience.2005.02.028","title":"Involvement of extracellular signal-regulated kinases 1/2 and (phosphoinositide 3-kinase)/Akt signal pathways in acquired resistance against neurotoxin of 6-hydroxydopamine in SH-SY5Y cells following cell-cell interaction with astrocytes","year":2005,"lang":"en","type":"article","venue":"Neuroscience","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"SH-SY5Y; Protein kinase B; Biology; Kinase; Cell biology; Signal transduction; PI3K/AKT/mTOR pathway; Neurotoxin; Hydroxydopamine; Phosphorylation; Neuroprotection; Molecular biology; Cell culture; Biochemistry; Endocrinology; Neuroscience; Neuroblastoma; Dopamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001509229,0.0003161939,0.0002736796,0.0001789124,0.0002220479,0.0002718471,0.0002022684,0.0002830315,0.0009951697],"category_scores_gemma":[0.0001015818,0.0001837467,0.0003342917,0.0001224335,0.0001813553,0.0003172425,0.0001776072,0.0005245729,0.000225501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002505248,"about_ca_system_score_gemma":0.0002164914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000792458,"about_ca_topic_score_gemma":0.0009721919,"domain_scores_codex":[0.999873,0.00002506779,0.00001452183,0.00001678207,0.00002558838,0.00004494247],"domain_scores_gemma":[0.9999266,0.000009230744,0.0000187762,0.00001035353,0.00001193358,0.0000231454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006263822,0.00004212032,0.000276273,0.00003728793,0.00001307144,0.0002352278,0.00003222272,0.00004685339,0.9979075,0.00022349,0.00001917108,0.0005404901],"study_design_scores_gemma":[0.00004638983,0.0003419639,0.008822683,0.00000388776,0.00003491864,0.0004654942,0.00006288377,0.0008408285,0.9886651,0.00008367803,0.0006279972,0.000004143914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977573,0.000755151,0.0005665583,0.00004741174,0.00001573764,0.00001133144,0.0001086919,0.00001631023,0.0007216433],"genre_scores_gemma":[0.9974526,0.0004566001,0.0004551971,0.00001561096,0.000005809746,0.00002292616,0.0001674704,0.000004136442,0.001419571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009951697,"threshold_uncertainty_score":0.003329158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009227336201885938,"score_gpt":0.2063766090610625,"score_spread":0.1971492728591766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}