{"id":"W2038735530","doi":"10.1007/s00401-014-1336-5","title":"Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress","year":2014,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":340,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Robert Packard Center for ALS Research, Johns Hopkins University; National Institute of Neurological Disorders and Stroke; National Institute on Aging; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; National Institutes of Health; Johns Hopkins University; Siragusa Foundation; Target ALS; U.S. Department of Defense","keywords":"C9orf72; Unfolded protein response; Ran; Neurotoxicity; Endoplasmic reticulum; Translation (biology); Biology; Neurite; Neurodegeneration; Trinucleotide repeat expansion; Proteasome; Amyotrophic lateral sclerosis; Frontotemporal dementia; Cell biology; Stress granule; Genetics; Chemistry; Gene; Dementia; Messenger RNA; Medicine; Disease; Toxicity; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03532450349502488,"score_gpt":0.2891918804136668,"score_spread":0.253867376918642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}