{"id":"W2038739322","doi":"10.1523/jneurosci.1501-13.2013","title":"PAK Inactivation Impairs Social Recognition in 3xTg-AD Mice without Increasing Brain Deposition of Tau and A ","year":2013,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut Universitaire en Santé Mentale de Québec; Université Laval; Centre hospitalier de l'Université Laval","funders":"National Institute on Aging","keywords":"Cofilin; Neocortex; Cortex (anatomy); Cognitive impairment; Cerebral cortex; Tau protein; Neuroscience; Internal medicine; Cognition; Endocrinology; Medicine; Psychology; Chemistry; Pathology; Disease; Alzheimer's disease; Actin cytoskeleton; Biochemistry; Cytoskeleton; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002683249,0.001563876,0.0006001721,0.001520233,0.0004483402,0.0005395529,0.0004814907,0.001040372,0.003498825],"category_scores_gemma":[0.0001892502,0.0005283824,0.0006242992,0.0004431078,0.0007763391,0.0004881486,0.0003679359,0.001516059,0.0009591678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006353114,"about_ca_system_score_gemma":0.0003525626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002078986,"about_ca_topic_score_gemma":0.00283883,"domain_scores_codex":[0.999604,0.00004069921,0.00005636403,0.0001070614,0.00008835416,0.000103566],"domain_scores_gemma":[0.9993407,0.00005058792,0.0002813912,0.00004448652,0.00003524487,0.0002475624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007418889,0.0003181465,0.0003870018,0.00002984572,0.00001883889,0.0002068466,0.00007182684,0.00005768593,0.9971915,0.0001365497,0.00008985808,0.000750002],"study_design_scores_gemma":[0.000299072,0.004067163,0.05402202,0.00006253,0.0001264286,0.001821571,0.0003275728,0.003599789,0.9326866,0.0004109477,0.00252679,0.00004952444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970975,0.0003541908,0.0006309681,0.000120394,0.00003170067,0.00003176504,0.0008239805,0.0001957651,0.0007137145],"genre_scores_gemma":[0.9898174,0.0004745648,0.001798309,0.0001369429,0.00003122211,0.0001193638,0.00113035,0.000161086,0.006330748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003498825,"threshold_uncertainty_score":0.01170474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03882826488460392,"score_gpt":0.3298580500870557,"score_spread":0.2910297852024517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}