{"id":"W2038828342","doi":"10.1016/j.bmcl.2007.01.021","title":"Design and synthesis of β-methoxyacrylate analogues via click chemistry and biological evaluations","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Plant Biotechnology Institute","funders":"Luonnontieteiden ja Tekniikan Tutkimuksen Toimikunta; Natural Sciences and Engineering Research Council of Canada","keywords":"Click chemistry; Chemistry; Antifungal; Triazole; Alkyne; Combinatorial chemistry; Azide; Biological activity; Chemical synthesis; Stereochemistry; Organic chemistry; In vitro; Biochemistry; Catalysis; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004105367,0.0003342617,0.0002551862,0.0001703455,0.0001367207,0.0002124907,0.0003084107,0.0002922667,0.002247885],"category_scores_gemma":[0.0003810552,0.000167113,0.0002990459,0.0001403682,0.0001683831,0.0003615725,0.00016057,0.0005019662,0.0004463281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000167929,"about_ca_system_score_gemma":0.0001948547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002712167,"about_ca_topic_score_gemma":0.0003278539,"domain_scores_codex":[0.9998782,0.00002488926,0.00001487798,0.00002021037,0.00003029492,0.00003148651],"domain_scores_gemma":[0.9998287,0.00003627893,0.00004658067,0.0000201831,0.00003086241,0.0000373677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003944403,0.0001557253,0.0001593682,0.00009448469,0.000009664192,0.0001803317,0.00003232813,0.001125489,0.9905804,0.0006836466,0.0001210804,0.006463076],"study_design_scores_gemma":[0.00006605402,0.001229366,0.0003596518,0.000004801178,0.00001670599,0.0001871206,0.00000881157,0.001098455,0.993782,0.00005972978,0.003179419,0.000007900072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757421,0.001709513,0.01610629,0.0001599996,0.000116421,0.0003549657,0.00038232,0.0001485812,0.005279761],"genre_scores_gemma":[0.9848483,0.001275889,0.008933786,0.0000775543,0.00002441085,0.0001337483,0.0003803259,0.00002651239,0.004299571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002247885,"threshold_uncertainty_score":0.007519901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03027408890982039,"score_gpt":0.2854294438803693,"score_spread":0.255155354970549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}