{"id":"W2038900290","doi":"10.1021/bi035296a","title":"Glutamate 346 of Human Na<sup>+</sup>−H<sup>+</sup> Exchanger NHE1 Is Crucial for Modulating both the Affinity for Na<sup>+</sup> and the Interaction with Amiloride Derivatives","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Mutant; Amino acid; Wild type; Sodium–hydrogen antiporter; Methane sulfonate; Guanidine; Amiloride; Stereochemistry; Sodium; Mutation; Crystallography; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005497884,0.0004581912,0.0004225286,0.00004851628,0.0005642214,0.00007814105,0.0003002506,0.0003619845,0.00004068121],"category_scores_gemma":[0.0001715572,0.0003219642,0.0002823949,0.0001559694,0.0004597637,0.00003074014,0.00006507451,0.0002031992,8.6797e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004297523,"about_ca_system_score_gemma":0.000112758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004351147,"about_ca_topic_score_gemma":0.000006998851,"domain_scores_codex":[0.9979047,0.00009061526,0.000562285,0.0006875672,0.0002772428,0.0004775826],"domain_scores_gemma":[0.9985304,0.0001239013,0.0003737859,0.0005712541,0.000296561,0.0001040611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005412461,0.0003940171,0.003583004,0.001462967,0.0009386496,0.000003378825,0.009535646,0.0125866,0.9599721,0.0008133803,0.002443935,0.002853889],"study_design_scores_gemma":[0.003706908,0.000388565,0.0002777624,0.0001546188,0.0001850542,0.0000242206,0.004952942,0.01978307,0.9667814,0.0004104023,0.002822794,0.0005122772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929162,0.000514306,0.004658442,0.0003451304,0.000063475,0.0009523237,0.0002080935,0.00002968847,0.0003123859],"genre_scores_gemma":[0.9965852,0.00007226945,0.0009015128,0.0002459262,0.0006281399,0.0003066774,0.0005272321,0.00007363126,0.00065945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007196467,"threshold_uncertainty_score":0.9999232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01700522382838207,"score_gpt":0.2548861201555418,"score_spread":0.2378808963271597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}