{"id":"W2038900788","doi":"10.1021/bi052267m","title":"A Glutamine to Glutamate Mutation at Position 170 (Q170E) in the Rabbit Na<sup>+</sup>/Glucose Cotransporter, rSGLT1, Enhances Binding Affinity for Na<sup>+</sup>","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Symporter; Glutamine; Biophysics; Asparagine; Sodium; Cotransporter; Allosteric regulation; Stereochemistry; Biochemistry; Amino acid; Enzyme; Transporter; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004187812,0.0004066262,0.0002893462,0.00009563006,0.0002720333,0.00006623338,0.0003424584,0.0004307134,0.00004343586],"category_scores_gemma":[0.0000306092,0.0003736898,0.0002364944,0.0003063858,0.0001009589,0.00002231317,0.00003554475,0.0001439469,0.00001825133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001178284,"about_ca_system_score_gemma":0.00009083046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008606764,"about_ca_topic_score_gemma":0.000073792,"domain_scores_codex":[0.9977331,0.00005598742,0.0005872828,0.0007284331,0.0003486459,0.0005465975],"domain_scores_gemma":[0.9990674,0.00003890891,0.000182431,0.0004510292,0.0001502496,0.000109958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005028457,0.0002166444,0.001397897,0.0001993726,0.00003548711,0.00001935054,0.0003922343,0.004698087,0.9908654,0.00002234698,0.00102114,0.0006292028],"study_design_scores_gemma":[0.001460565,0.0002048253,0.002540816,0.00009607626,0.00006612697,0.00004707414,0.0005308879,0.002209446,0.9905555,0.00006774921,0.001773833,0.0004471024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944953,0.0004367779,0.003167125,0.0004306793,0.00008223356,0.0007140225,0.0004169383,0.00004555369,0.0002113112],"genre_scores_gemma":[0.9893824,0.00005017972,0.0004962125,0.0002528516,0.0006050206,0.0002458483,0.007910115,0.00005075878,0.001006596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007493176,"threshold_uncertainty_score":0.9998715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007825350552284187,"score_gpt":0.2309954190167738,"score_spread":0.2231700684644896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}