{"id":"W2038900788","doi":"10.1021/bi052267m","title":"A Glutamine to Glutamate Mutation at Position 170 (Q170E) in the Rabbit Na<sup>+</sup>/Glucose Cotransporter, rSGLT1, Enhances Binding Affinity for Na<sup>+</sup>","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Symporter; Glutamine; Biophysics; Asparagine; Sodium; Cotransporter; Allosteric regulation; Stereochemistry; Biochemistry; Amino acid; Enzyme; Transporter; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001867124,0.0003859688,0.0002322488,0.0001051755,0.00007769835,0.0002495999,0.0002832702,0.0003457408,0.001027499],"category_scores_gemma":[0.0002368551,0.0001554904,0.0002922205,0.0001339373,0.0004381558,0.0001944685,0.0002312214,0.0003980962,0.0005417552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002863988,"about_ca_system_score_gemma":0.0002133169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007202129,"about_ca_topic_score_gemma":0.0009022192,"domain_scores_codex":[0.9998401,0.00003557638,0.00002797404,0.00002785669,0.00004249769,0.00002588383],"domain_scores_gemma":[0.9997999,0.00004857157,0.00008425198,0.00001651011,0.00001421806,0.00003663243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006000536,0.00001039331,0.0001266382,0.00001165725,0.000003891484,0.00006243856,0.000008030658,0.00002917839,0.9993388,0.00004235325,0.00000962933,0.0002968987],"study_design_scores_gemma":[0.00003133517,0.0003510005,0.003271145,0.000004250531,0.00001878688,0.001005464,0.00003195292,0.0007416078,0.9933985,0.00003440096,0.001104528,0.000006822856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975525,0.0001757482,0.001585037,0.00005663839,0.00001737753,0.0000200655,0.0001523051,0.00004066036,0.0003996508],"genre_scores_gemma":[0.9964764,0.0001842346,0.002215626,0.00006362582,0.00000605384,0.00001504032,0.0003041477,0.00003454476,0.0007003794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001027499,"threshold_uncertainty_score":0.00343734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007825350552284187,"score_gpt":0.2309954190167738,"score_spread":0.2231700684644896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}