{"id":"W2038933726","doi":"10.1006/exnr.2000.7322","title":"Despite the Internucleosomal Cleavage of DNA, Reactive Oxygen Species Do Not Produce Other Markers of Apoptosis in Cultured Neurons","year":2000,"lang":"en","type":"article","venue":"Experimental Neurology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Biological Sciences","funders":"","keywords":"Apoptosis; Aurintricarboxylic acid; Programmed cell death; Peroxynitrite; Reactive oxygen species; Apoptotic DNA fragmentation; Staurosporine; Biology; DNA laddering; Molecular biology; DNA fragmentation; TUNEL assay; In Situ Nick-End Labeling; Cycloheximide; Cell biology; Biochemistry; Chemistry; Superoxide; Signal transduction; Protein biosynthesis; Protein kinase C","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004676779,0.0003900386,0.0003766632,0.0003107162,0.0002913795,0.0004857872,0.0003637933,0.000471672,0.001909137],"category_scores_gemma":[0.0006217139,0.0002205103,0.0003105901,0.000278129,0.0003582914,0.0005717346,0.0002338425,0.001334328,0.0007656822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000364955,"about_ca_system_score_gemma":0.0003179226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008806306,"about_ca_topic_score_gemma":0.00155956,"domain_scores_codex":[0.9995822,0.00005352786,0.00006279419,0.00007122276,0.0001677718,0.00006249869],"domain_scores_gemma":[0.998849,0.0003291519,0.0001652388,0.0002506722,0.0002930065,0.0001127913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002193454,0.00005065447,0.0004719943,0.00007106543,0.00002333627,0.000138153,0.00008822687,0.00004319286,0.9956958,0.000264055,0.00006273021,0.002871448],"study_design_scores_gemma":[0.00001256194,0.0002212812,0.002104951,0.000007701259,0.00001692329,0.0003163226,0.00005756357,0.0001460558,0.9958662,0.0001713235,0.001076036,0.000002961546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684458,0.003180632,0.02024418,0.0002575898,0.0002189543,0.00006638362,0.0006280866,0.0001733041,0.006785004],"genre_scores_gemma":[0.9757602,0.001888218,0.01180452,0.0001389758,0.00005407505,0.0001207334,0.001291237,0.00007540563,0.008866709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001909137,"threshold_uncertainty_score":0.006386697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03678763965355199,"score_gpt":0.3188461746954074,"score_spread":0.2820585350418554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}