{"id":"W2038964762","doi":"10.1016/j.vaccine.2009.10.134","title":"Design and delivery of a cryptic PrPC epitope for induction of PrPSc-specific antibody responses","year":2009,"lang":"en","type":"article","venue":"Vaccine","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia Hospital; University of Alberta; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Ministry of Agriculture - Saskatchewan; University of Saskatchewan","keywords":"Immunogenicity; Epitope; Antibody; Virology; Immune system; Antigen; Immunology; Adjuvant; Biology; Immunotherapy; Recombinant DNA; Conformational epitope; Vaccination; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001586646,0.00006921474,0.0001148976,0.00004489093,0.00002696897,0.000004788926,0.00005753189,0.0000608424,0.000009068052],"category_scores_gemma":[0.00005064543,0.00006314246,0.00004134722,0.0000543156,0.000007436459,0.000003808012,0.00001885521,0.00002061569,2.565777e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002936767,"about_ca_system_score_gemma":0.00003093161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003050696,"about_ca_topic_score_gemma":1.828189e-7,"domain_scores_codex":[0.9995201,0.00004112856,0.0001583963,0.0001484232,0.000043826,0.00008818969],"domain_scores_gemma":[0.9996266,0.00002275332,0.00008738616,0.0001464844,0.00008463098,0.00003217734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001271174,0.00003923626,0.0003826235,0.00002808072,0.00001619418,4.102841e-7,0.00001279493,0.00002502403,0.9388161,0.0000440764,0.000298512,0.05906572],"study_design_scores_gemma":[0.000958053,0.001314652,0.0154131,0.00004089816,0.00002395177,0.000005691147,0.00001793552,0.0001163939,0.9760963,0.0003626425,0.005553797,0.00009660091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717616,0.0150967,0.01265909,0.0001204981,0.00002979752,0.0003131434,0.000008884939,0.000003968343,0.000006310817],"genre_scores_gemma":[0.9884775,0.004756968,0.006582131,0.00003365714,0.00007203432,0.000007102595,0.00002024411,0.000006260611,0.00004406925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05896912,"threshold_uncertainty_score":0.2574875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02138431088413922,"score_gpt":0.2821748186900656,"score_spread":0.2607905078059264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}