{"id":"W2038964762","doi":"10.1016/j.vaccine.2009.10.134","title":"Design and delivery of a cryptic PrPC epitope for induction of PrPSc-specific antibody responses","year":2009,"lang":"en","type":"article","venue":"Vaccine","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia Hospital; University of Alberta; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Ministry of Agriculture - Saskatchewan; University of Saskatchewan","keywords":"Immunogenicity; Epitope; Antibody; Virology; Immune system; Antigen; Immunology; Adjuvant; Biology; Immunotherapy; Recombinant DNA; Conformational epitope; Vaccination; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002860686,0.0003336192,0.0002989809,0.0002142891,0.0002847516,0.0003518961,0.0004426244,0.0005288571,0.0007687939],"category_scores_gemma":[0.0001667272,0.0002658721,0.0002923922,0.0001839776,0.0002618398,0.000200643,0.000211006,0.001002171,0.0004058387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005958093,"about_ca_system_score_gemma":0.0004189434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006271591,"about_ca_topic_score_gemma":0.0008815923,"domain_scores_codex":[0.9998709,0.00002269756,0.00001391905,0.0000244652,0.00003058812,0.00003733053],"domain_scores_gemma":[0.999916,0.000011598,0.00002262349,0.00001077663,0.00001608038,0.00002293498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001176435,0.00009038537,0.00006808541,0.00003953449,0.00000612913,0.00006378653,0.00001708147,0.0007184606,0.9961688,0.0005674349,0.00007719908,0.002065346],"study_design_scores_gemma":[0.0000752953,0.0004951878,0.0002813796,0.000006361641,0.00002046929,0.0001684112,0.00001251218,0.003104975,0.992751,0.0001227249,0.002953853,0.000007871244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9596726,0.0008010403,0.03657317,0.000384851,0.0001023587,0.0003255214,0.0003026055,0.0001529502,0.001684957],"genre_scores_gemma":[0.9752425,0.0004373606,0.02164877,0.0001294322,0.0000173793,0.0001268823,0.0002997476,0.00002605794,0.002071804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007687939,"threshold_uncertainty_score":0.004322886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02138431088413922,"score_gpt":0.2821748186900656,"score_spread":0.2607905078059264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}