{"id":"W2038974658","doi":"10.1074/jbc.m113.486654","title":"Aggregatibacter actinomycetemcomitans Leukotoxin Utilizes a Cholesterol Recognition/Amino Acid Consensus Site for Membrane Association","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Eye Institute; National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research","keywords":"Aggregatibacter actinomycetemcomitans; Association (psychology); Chemistry; Cholesterol; Biology; Biochemistry; Bacteria; Genetics; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002822904,0.0002214181,0.0003449175,0.00002284042,0.00007145074,0.00005658841,0.0002032017,0.0005109135,0.000280419],"category_scores_gemma":[0.0006319742,0.0001588738,0.0003276479,0.00005385781,0.00006997002,0.00001138853,0.00004633391,0.0002573071,0.00001410766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005612554,"about_ca_system_score_gemma":0.00007002052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003132552,"about_ca_topic_score_gemma":0.000001299681,"domain_scores_codex":[0.9986759,0.00006024682,0.0005405526,0.0002571143,0.0001571857,0.0003089607],"domain_scores_gemma":[0.998422,0.00009694484,0.0006798555,0.000177029,0.0004658985,0.000158274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001713763,0.00007385031,0.006709597,0.00004169469,0.00009184075,0.000003029864,0.00001493045,6.344433e-7,0.9879335,1.362875e-7,0.001428273,0.003531205],"study_design_scores_gemma":[0.001424767,0.0003082834,0.00686524,0.000032462,0.00006948269,0.0002114965,0.00007009816,0.000002738551,0.9843542,0.00003646503,0.006412352,0.0002124236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984707,0.0001021697,0.00004311318,0.0004426611,0.0002032529,0.0002482637,0.00009255378,0.00001050433,0.0003867287],"genre_scores_gemma":[0.9963465,0.00009404893,0.00120287,0.00038032,0.001098034,0.00003368851,0.000166863,0.00001618347,0.0006615063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004984079,"threshold_uncertainty_score":0.6478685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02412183783665837,"score_gpt":0.2514640185784928,"score_spread":0.2273421807418344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}