{"id":"W2038977836","doi":"10.1007/s00210-006-0101-2","title":"Disease modifying genes in cystic fibrosis: therapeutic option or one-way road?","year":2006,"lang":"en","type":"review","venue":"Naunyn-Schmiedeberg s Archives of Pharmacology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Disease; Gene; Pathophysiology; Medicine; Bioinformatics; Lung disease; Lung; Biology; Immunology; Genetics; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003981935,0.0009394234,0.003503114,0.001721238,0.0001314145,0.00003570526,0.0007379767,0.0003551797,0.0005346343],"category_scores_gemma":[0.0002710602,0.0007405636,0.0009071028,0.0009138384,0.0006814153,0.0001735196,0.0003603269,0.00127036,0.00006245536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003219307,"about_ca_system_score_gemma":0.001639237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001403626,"about_ca_topic_score_gemma":0.00005588687,"domain_scores_codex":[0.9938153,0.001125052,0.00185983,0.001209274,0.0007564925,0.001234052],"domain_scores_gemma":[0.995647,0.002351137,0.0007602802,0.0006399198,0.0001004437,0.0005012428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00369975,0.001116225,0.00006793836,0.05090424,0.0006599458,0.0003341849,0.00006679857,0.0002701191,0.005231312,0.0001317831,0.0003465707,0.9371711],"study_design_scores_gemma":[0.004860437,0.001198309,0.001102267,0.02437949,0.004559803,0.0001086693,0.00002429216,0.002891276,0.0006498656,0.0006446712,0.9585504,0.001030538],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004359286,0.9935904,0.0007274322,0.0002000324,0.0004503197,0.003499205,0.0002390018,0.000110968,0.0007467112],"genre_scores_gemma":[0.00256604,0.9867923,0.005803541,0.000119888,0.0007087336,0.001761209,0.0005802959,0.0001880648,0.001479879],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9582038,"threshold_uncertainty_score":0.9995046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06630224169131255,"score_gpt":0.4071096913908396,"score_spread":0.340807449699527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}