{"id":"W2039002053","doi":"10.1073/pnas.1308497110","title":"REGγ deficiency promotes premature aging via the casein kinase 1 pathway","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Fundamental Research Funds for the Central Universities; Canadian Institutes of Health Research; National Key Research and Development Program of China; National Cancer Institute; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Science and Technology Commission of Shanghai Municipality; National Natural Science Foundation of China","keywords":"Casein kinase 1; Proteasome; Mdm2; Gene silencing; Activator (genetics); Biology; Phenotype; Premature aging; Senescence; Kinase; Cell biology; Casein kinase 2; Cancer research; Genetics; Protein kinase A; Gene; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012245,0.000541986,0.0001967086,0.0002837657,0.0001084546,0.0002497432,0.000135599,0.0002019216,0.001148887],"category_scores_gemma":[0.00007307615,0.0001647821,0.0002304834,0.00008505466,0.0002406394,0.0001135736,0.0002289935,0.0003757927,0.000340074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002240764,"about_ca_system_score_gemma":0.0001419298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002633006,"about_ca_topic_score_gemma":0.0004008749,"domain_scores_codex":[0.9999295,0.00001344664,0.000006673323,0.00001815125,0.00001507599,0.00001718148],"domain_scores_gemma":[0.9999132,0.00001012506,0.00003436421,0.00001037342,0.000005615027,0.00002634871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001795676,0.00001475414,0.000347913,0.00003907252,0.000009859184,0.0001487227,0.000009106809,0.00006202832,0.9976664,0.0001078245,0.00005501791,0.001359724],"study_design_scores_gemma":[0.00003345503,0.0003238291,0.01813625,0.00002073699,0.00004735929,0.001230318,0.00004407246,0.0009378961,0.9736719,0.0002373219,0.005308311,0.000008560213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915046,0.003821116,0.002166819,0.0001755096,0.00003182273,0.00001808454,0.0004247365,0.0002613415,0.00159603],"genre_scores_gemma":[0.992834,0.002636394,0.001094808,0.00007393462,0.00001013427,0.00002194486,0.0004089505,0.00002634428,0.002893515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001148887,"threshold_uncertainty_score":0.003843367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02290455088091333,"score_gpt":0.2663508227064932,"score_spread":0.2434462718255798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}