{"id":"W2039004712","doi":"10.1016/j.vascn.2013.05.002","title":"Safety pharmacology investigations in toxicology studies: An industry survey","year":2013,"lang":"en","type":"article","venue":"Journal of Pharmacological and Toxicological Methods","topic":"Immunotoxicology and immune responses","field":"Immunology and Microbiology","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"Armand Frappier Museum","funders":"","keywords":"Safety pharmacology; Regulatory agency; Toxicology; Agency (philosophy); Pharmacology; Chemical safety; Medicine; Clinical pharmacology; Pharmaceutical industry; Psychology; Drug; Risk analysis (engineering); Biology; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.02505162,0.0006446025,0.0005533451,0.008356964,0.001158584,0.001902874,0.001034402,0.001568655,0.003388035],"category_scores_gemma":[0.03340412,0.0003579413,0.001187037,0.005353251,0.001499631,0.001687033,0.001943951,0.001245856,0.0008790948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001564669,"about_ca_system_score_gemma":0.004525832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002041467,"about_ca_topic_score_gemma":0.003734448,"domain_scores_codex":[0.9807324,0.006639387,0.002920388,0.001661603,0.007504554,0.000541714],"domain_scores_gemma":[0.8587582,0.07233273,0.02074531,0.006564194,0.03867378,0.002925914],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0008386364,0.001137708,0.2829642,0.002130863,0.000284337,0.001233841,0.001772116,0.001184198,0.03647814,0.001810633,0.002598493,0.6675668],"study_design_scores_gemma":[0.00012375,0.008630086,0.6459015,0.004147499,0.001179673,0.01583259,0.006432029,0.002180301,0.09562148,0.003025813,0.2167986,0.0001266217],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7643577,0.1389946,0.02436411,0.00919167,0.00022472,0.0009554579,0.002090548,0.0003891493,0.05943207],"genre_scores_gemma":[0.8915645,0.080966,0.01303794,0.005203875,0.0003484421,0.0002519777,0.002069235,0.0001344868,0.006423496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9749484,"threshold_uncertainty_score":0.1324872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.150382406847304,"score_gpt":0.4555436111756173,"score_spread":0.3051612043283133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}