{"id":"W2039014468","doi":"10.1111/j.1747-0285.2009.00919.x","title":"N‐Methylated Cyclic Enkephalin Analogues Retain High Opioid Receptor Binding Affinity","year":2009,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Enkephalin; Chemistry; Opioid; Receptor; Opioid receptor; Stereochemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001098955,0.0001805589,0.0001889339,0.00005017333,0.00007648896,0.00015612,0.0002096881,0.0001574517,0.0008125261],"category_scores_gemma":[0.0001706592,0.00008253855,0.0001466565,0.00006033815,0.0001368017,0.0001411837,0.0001009155,0.0003787729,0.0002195555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001837837,"about_ca_system_score_gemma":0.0001431012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004315881,"about_ca_topic_score_gemma":0.00102696,"domain_scores_codex":[0.9999301,0.000013098,0.000006815922,0.00001305577,0.00002072536,0.00001619947],"domain_scores_gemma":[0.9998896,0.0000234406,0.00003803685,0.00001386337,0.00001529043,0.00001982737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008510133,0.000008824727,0.0000507721,0.00001320284,0.000002625806,0.00001574207,0.000006974759,0.00006583187,0.9989059,0.00002574281,0.000006374534,0.0008129651],"study_design_scores_gemma":[0.0000218335,0.0007834442,0.001868919,0.000003315853,0.00001574405,0.0002116453,0.00001626045,0.0003891579,0.9950655,0.00002106801,0.001598241,0.000004891423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975153,0.0005471857,0.001038483,0.00001840785,0.00000618285,0.00001344891,0.00008836854,0.00001075417,0.0007619047],"genre_scores_gemma":[0.9957598,0.0004180511,0.002010012,0.00003170119,0.00000586549,0.00001623956,0.000252779,0.000009881269,0.001495773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008125261,"threshold_uncertainty_score":0.00271821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04045595877241948,"score_gpt":0.2724091797367468,"score_spread":0.2319532209643274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}