{"id":"W2039018328","doi":"10.1016/j.str.2004.04.018","title":"Pathway Complexity of Alzheimer's β-Amyloid Aβ16-22 Peptide Assembly","year":2004,"lang":"en","type":"article","venue":"Structure","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Regroupement Québécois sur les Matériaux de Pointe","funders":"","keywords":"Peptide; Amyloid (mycology); P3 peptide; Alzheimer's disease; Chemistry; Amyloid precursor protein; Biochemistry; Neuroscience; Cell biology; Computational biology; Biology; Medicine; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005667842,0.0002341114,0.0004162014,0.00009971137,0.0001010869,0.00001439023,0.0001284302,0.0001204435,0.0007441906],"category_scores_gemma":[0.00004139876,0.0001778372,0.0001901288,0.0002275258,0.0003100923,0.0000898266,0.00006644334,0.0002595496,0.0000586162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007897857,"about_ca_system_score_gemma":0.0005128683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002304779,"about_ca_topic_score_gemma":0.00005345852,"domain_scores_codex":[0.9983752,0.00003893983,0.000262127,0.0003206973,0.0005847007,0.0004183317],"domain_scores_gemma":[0.9988039,0.00001779311,0.0001028317,0.0004819497,0.000174712,0.0004187742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.009389844,0.008745812,0.2587622,0.002613086,0.182912,0.009104777,0.00484923,0.000617585,0.3186002,0.12931,0.01756397,0.05753133],"study_design_scores_gemma":[0.01277838,0.001666109,0.5865228,0.0003281952,0.0020903,0.0003807951,0.0003807069,0.00003106024,0.3354768,0.05832285,0.001408194,0.0006137724],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869162,0.005231041,0.00002497448,0.0006296475,0.00010668,0.0005798197,0.0004555811,0.00007859698,0.005977424],"genre_scores_gemma":[0.9970481,0.00003116791,0.002276468,0.0001579221,0.000153192,0.000009226916,0.0002629447,0.00003201912,0.00002893753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3277607,"threshold_uncertainty_score":0.8148366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0427600435533114,"score_gpt":0.316617347175627,"score_spread":0.2738573036223156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}