{"id":"W2039055784","doi":"10.1021/bc060053r","title":"HIV-1 Tat Peptide Immunoconjugates Differentially Sensitize Breast Cancer Cells to Selected Antiproliferative Agents That Induce the Cyclin-Dependent Kinase Inhibitor p21<sup>WAF-1/CIP-1</sup>","year":2006,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Chemistry; Camptothecin; Cyclin B1; Cell cycle; Growth inhibition; Epidermal growth factor; Molecular biology; Cell growth; Cancer cell; Cyclin-dependent kinase 1; Cancer research; Cell; Cancer; Biochemistry; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001193759,0.0003117881,0.0002414677,0.000139389,0.0001384369,0.0003036315,0.0001266105,0.0002535963,0.001012697],"category_scores_gemma":[0.0001181784,0.0001507444,0.0001717896,0.0001355596,0.0001383529,0.000163853,0.00008835438,0.0005012428,0.0003142354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002398931,"about_ca_system_score_gemma":0.0001333175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002927434,"about_ca_topic_score_gemma":0.0004032934,"domain_scores_codex":[0.9998624,0.00002783389,0.0000101884,0.00002518153,0.00003542148,0.00003902141],"domain_scores_gemma":[0.9999024,0.00002854195,0.00002388263,0.00001300345,0.00001553269,0.00001674696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005944187,0.00002437731,0.00008917837,0.0000202648,0.000004511995,0.00002566936,0.00001036219,0.00004974897,0.9988973,0.00003507124,0.00002218257,0.0007618289],"study_design_scores_gemma":[0.000006395554,0.000318968,0.001138811,0.000001832528,0.00001169947,0.000209945,0.000009708173,0.0002162292,0.9968199,0.000009455784,0.001255582,0.000001613943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957128,0.001853313,0.001366764,0.00006460653,0.00003568851,0.00002917181,0.00009599484,0.00003451015,0.0008072767],"genre_scores_gemma":[0.9939892,0.001488987,0.002349026,0.00006838633,0.00001454838,0.0000352906,0.0003855829,0.00001765014,0.001651354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001012697,"threshold_uncertainty_score":0.003387749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0102698867420769,"score_gpt":0.2338556274830206,"score_spread":0.2235857407409436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}