{"id":"W2039086898","doi":"10.1111/j.1471-4159.2008.05470.x","title":"Forskolin induction of late‐LTP and up‐regulation of 5′ TOP mRNAs translation via mTOR, ERK, and PI3K in hippocampal pyramidal cells","year":2008,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; Université Laval; Armand Frappier Museum; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Long-term potentiation; PI3K/AKT/mTOR pathway; Hippocampal formation; Forskolin; Cell biology; P70-S6 Kinase 1; LTP induction; Biology; Synaptic plasticity; Chemistry; Neuroscience; Signal transduction; Biochemistry; Receptor; Stimulation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002286214,0.0001180112,0.0002501883,0.0002036865,0.00006849232,0.00001075512,0.0001681811,0.0000908545,0.00001527586],"category_scores_gemma":[0.0001734618,0.0001117282,0.00005458139,0.0003473044,0.0004376354,0.000331445,0.00003822448,0.0004167314,3.694802e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001206979,"about_ca_system_score_gemma":0.00008478703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002630988,"about_ca_topic_score_gemma":3.096767e-7,"domain_scores_codex":[0.9985125,0.0001237213,0.000531965,0.0002374551,0.0004073465,0.000186991],"domain_scores_gemma":[0.9990926,0.0002226761,0.0003939807,0.0001004071,0.0000858326,0.0001045227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002677598,0.0000962459,0.003035764,0.00006787812,0.000001637559,0.00006864492,0.0002907933,0.00009599367,0.99481,0.000001991834,0.00002565566,0.001237616],"study_design_scores_gemma":[0.0009976729,0.0002522125,0.03426429,0.00002416845,0.000009842751,0.0007885078,0.00001929751,0.001274749,0.9621283,0.0001404045,0.00003007193,0.00007049061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993134,0.00006131923,0.00004385926,0.0001787522,0.0002448408,0.00009662013,0.000003762701,0.000004594999,0.00005287756],"genre_scores_gemma":[0.9990951,0.0006464388,0.00004170752,0.00006963572,0.00006567403,9.946961e-7,1.732676e-7,0.00001051925,0.00006977849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03268173,"threshold_uncertainty_score":0.4556144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05312592942209604,"score_gpt":0.3056189206352523,"score_spread":0.2524929912131562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}