{"id":"W2039103666","doi":"10.1038/sj.tpj.6500416","title":"Analysis of a missense variant of the human N-formyl peptide receptor that is associated with agonist-independent β-arrestin association and indices of inflammation","year":2006,"lang":"en","type":"article","venue":"The Pharmacogenomics Journal","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Missense mutation; Agonist; Arrestin; Receptor; Peptide; B2 receptor; Inflammation; Association (psychology); Medicine; Pharmacology; Chemistry; Internal medicine; Endocrinology; G protein-coupled receptor; Mutation; Biochemistry; Psychology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001057377,0.0001042196,0.0002185056,0.0000770625,0.0001608066,0.00002510891,0.0001855094,0.00007690412,0.00006526544],"category_scores_gemma":[0.00003630888,0.00006434238,0.0001513745,0.0001722897,0.00005149705,0.000007652905,0.00005000155,0.0001345966,1.111519e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005184841,"about_ca_system_score_gemma":0.00006678713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000934231,"about_ca_topic_score_gemma":0.00008590123,"domain_scores_codex":[0.9989367,0.0001604812,0.0003909083,0.0001063708,0.0002755679,0.0001299721],"domain_scores_gemma":[0.9982253,0.00004012204,0.001388944,0.0001213692,0.0001935397,0.00003072408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000686852,0.00003631264,0.0178122,0.000007003857,0.001403981,0.000001017774,0.0003357788,0.002187169,0.9778184,0.00002918482,0.00008971102,0.0002105889],"study_design_scores_gemma":[0.000673574,0.00008211906,0.0136531,0.00002703321,0.001265411,0.00001911147,0.0001620266,0.0009114324,0.9828223,0.0001388459,0.0001576615,0.00008739503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989823,0.0002383037,0.0003189158,0.0001217539,0.00005760581,0.0001125453,0.00007988765,0.000001451268,0.00008730888],"genre_scores_gemma":[0.9994713,0.0001487024,0.00008377945,0.00002757502,0.0000908558,0.00000164574,0.00003452777,0.00001050158,0.0001311117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005003929,"threshold_uncertainty_score":0.2623806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01105553681467851,"score_gpt":0.2375958979922172,"score_spread":0.2265403611775387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}