{"id":"W2039103666","doi":"10.1038/sj.tpj.6500416","title":"Analysis of a missense variant of the human N-formyl peptide receptor that is associated with agonist-independent β-arrestin association and indices of inflammation","year":2006,"lang":"en","type":"article","venue":"The Pharmacogenomics Journal","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Missense mutation; Agonist; Arrestin; Receptor; Peptide; B2 receptor; Inflammation; Association (psychology); Medicine; Pharmacology; Chemistry; Internal medicine; Endocrinology; G protein-coupled receptor; Mutation; Biochemistry; Psychology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002790856,0.001443935,0.0007968901,0.0008919443,0.0007043143,0.0004951957,0.0006285662,0.002055928,0.002435526],"category_scores_gemma":[0.001255001,0.0002680304,0.001032988,0.0005088528,0.0008574201,0.0002222016,0.0004507457,0.0008137565,0.000659641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002772741,"about_ca_system_score_gemma":0.0003349702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001869238,"about_ca_topic_score_gemma":0.001307316,"domain_scores_codex":[0.9994739,0.0001119381,0.00009604074,0.0001522452,0.0001020541,0.00006385124],"domain_scores_gemma":[0.9986728,0.0004915672,0.0004394273,0.00007408769,0.00009148669,0.0002307359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003028308,0.0003821633,0.03170139,0.000156303,0.0006015031,0.2041356,0.000526265,0.0008518299,0.7503522,0.001048435,0.0007554605,0.006460541],"study_design_scores_gemma":[0.0004804978,0.003341647,0.2474284,0.0001103088,0.001052311,0.5437705,0.0007306561,0.008337292,0.1862504,0.0008603886,0.007408728,0.0002289678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949827,0.0003657009,0.002583025,0.0003066946,0.0001545751,0.00005896915,0.0007064269,0.00007089477,0.0007709658],"genre_scores_gemma":[0.9976652,0.0001167929,0.000892434,0.0001476092,0.00006478157,0.00001559739,0.0002722208,0.00003745882,0.0007879045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002435526,"threshold_uncertainty_score":0.008147657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01105553681467851,"score_gpt":0.2375958979922172,"score_spread":0.2265403611775387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}