{"id":"W2039185379","doi":"10.1038/clpt.2014.126","title":"Pharmacogenomics of Human Uridine Diphospho-Glucuronosyltransferases and Clinical Implications","year":2014,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":165,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Glucuronidation; Glucuronosyltransferase; Uridine; Pharmacogenomics; Clinical pharmacology; Uridine diphosphate; Pharmacology; Drug metabolism; Xenobiotic; Pharmacogenetics; Drug; Chemistry; Computational biology; Enzyme; Biochemistry; Biology; RNA; Gene; Microsome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004062519,0.0006198411,0.001353223,0.000190659,0.0005135266,0.00002667658,0.0009708835,0.0008868364,0.0009349204],"category_scores_gemma":[0.00008103128,0.0006082275,0.000615018,0.000359493,0.002522101,0.0001258622,0.0003278714,0.002162494,0.00009368435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003747086,"about_ca_system_score_gemma":0.000193364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009831851,"about_ca_topic_score_gemma":0.000005899565,"domain_scores_codex":[0.9924076,0.002798474,0.002615548,0.001041703,0.0002220541,0.0009146194],"domain_scores_gemma":[0.9936277,0.003787432,0.0007219385,0.0005569837,0.0003737453,0.0009322325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001407205,0.005522997,0.2538418,0.000136243,0.00373137,0.00001597829,0.0003066809,0.0001606347,0.5292439,0.003529006,0.01647162,0.1856325],"study_design_scores_gemma":[0.01583516,0.001683239,0.07815997,0.00001771047,0.008449194,0.00004160945,0.00004199094,0.004508688,0.1386058,0.003812147,0.7476942,0.001150331],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780274,0.004002979,0.0008536078,0.008466263,0.005459058,0.0009280212,0.0002337232,0.0001818151,0.001847153],"genre_scores_gemma":[0.9189858,0.02222854,0.0005497853,0.05567713,0.002129759,0.00006595726,0.00005959479,0.0001026624,0.0002008167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7312226,"threshold_uncertainty_score":0.9999784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2620271041099431,"score_gpt":0.5475852774856149,"score_spread":0.2855581733756718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}