{"id":"W2039191003","doi":"10.1038/sj.onc.1207517","title":"Role of AIF in caspase-dependent and caspase-independent cell death","year":2004,"lang":"en","type":"review","venue":"Oncogene","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":522,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; National Institutes of Health; Canadian Stroke Network; Heart and Stroke Foundation of Canada; Johns Hopkins University; Robert Packard Center for ALS Research, Johns Hopkins University; National Institute of Neurological Disorders and Stroke; American Heart Association","keywords":"Biology; Poly ADP ribose polymerase; Apoptosis-inducing factor; Caspase; Apoptosis; Programmed cell death; Cell biology; Mitochondrion; Effector; Signal transduction; Cancer research; Polymerase; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002025679,0.0003468352,0.0007458818,0.0001314135,0.00003285193,0.0000138344,0.0001687873,0.0005711153,0.00002505647],"category_scores_gemma":[0.000008854664,0.000302386,0.0002285173,0.0000899072,0.00002713656,0.000002355162,0.000171621,0.0001539098,0.000008462308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008198777,"about_ca_system_score_gemma":0.0003189199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002123685,"about_ca_topic_score_gemma":0.0002322541,"domain_scores_codex":[0.9984493,0.00007641188,0.0004900454,0.0005369734,0.0001927328,0.000254532],"domain_scores_gemma":[0.9991574,0.000009694966,0.0002826856,0.000405547,0.00004105659,0.0001035898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002946856,0.0003098987,0.00002070127,0.007191392,0.0001269235,0.00009344576,0.00005278554,0.0001095229,0.1191183,0.0001903538,0.0000203388,0.8727369],"study_design_scores_gemma":[0.002026299,0.0007538547,0.00004848682,0.004626464,0.0008457922,0.0005213656,0.00009071596,0.00002731573,0.09899399,0.0003752021,0.890401,0.001289495],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005707232,0.9927221,0.00009252116,0.000002642186,0.000108432,0.0005163813,0.00007310166,0.000005955058,0.0007716222],"genre_scores_gemma":[0.01550112,0.9827192,0.0004118448,0.000007528579,0.0001409028,0.00004289652,0.0003509397,0.00006051786,0.0007649949],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8903807,"threshold_uncertainty_score":0.9999428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01472485420343526,"score_gpt":0.2737680076970761,"score_spread":0.2590431534936408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}