{"id":"W2039196318","doi":"10.1016/j.pnpbp.2005.03.021","title":"Investigating responders to lithium prophylaxis as a strategy for mapping susceptibility genes for bipolar disorder","year":2005,"lang":"en","type":"review","venue":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; University of Toronto; Montreal General Hospital; University of Ottawa; Dalhousie University","funders":"Canadian Institutes of Health Research; Research Nova Scotia; National Alliance for Research on Schizophrenia and Depression","keywords":"Bipolar disorder; Lithium (medication); Mood stabilizer; Treatment of bipolar disorder; Mood; Family history; Genetic association; Family studies; Genetics; Gene; Medicine; Psychology; Psychiatry; Mania; Biology; Internal medicine; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007055484,0.0008542773,0.001959202,0.0004469502,0.0002770013,0.00004542519,0.0003274411,0.001129824,0.00005148376],"category_scores_gemma":[0.0002258636,0.0005882414,0.0006209008,0.0006443849,0.0005072358,0.00005687234,0.000132215,0.0009604233,0.00001271765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000077727,"about_ca_system_score_gemma":0.0004266101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005253637,"about_ca_topic_score_gemma":0.00005064063,"domain_scores_codex":[0.9955879,0.0004647966,0.001164793,0.001718647,0.0001545593,0.0009092865],"domain_scores_gemma":[0.9980094,0.0007005071,0.0003609659,0.000388319,0.0001059182,0.0004348794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008877041,0.001053912,0.2057941,0.007195655,0.0002515384,0.000004286157,0.00004369276,4.822775e-7,0.000003778719,0.0001468556,0.0002711614,0.7843469],"study_design_scores_gemma":[0.00446945,0.00590918,0.03012148,0.001331548,0.0006115446,0.0001001351,0.00006507429,0.00001613457,5.487302e-7,0.0009476895,0.9558048,0.0006224541],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01976862,0.9660955,0.00005781546,0.00200178,0.001130279,0.01056212,0.0002268175,0.0001275899,0.00002947006],"genre_scores_gemma":[0.002491788,0.9811919,0.007726059,0.001533039,0.0008443713,0.005789648,0.0002568305,0.0000910041,0.00007533629],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9555336,"threshold_uncertainty_score":0.9996569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09250858229837429,"score_gpt":0.4182716098505614,"score_spread":0.3257630275521871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}