{"id":"W2039208967","doi":"10.1016/j.imlet.2014.11.013","title":"Human megakaryocyte progenitors derived from hematopoietic stem cells of normal individuals are MHC class II-expressing professional APC that enhance Th17 and Th1/Th17 responses","year":2014,"lang":"en","type":"article","venue":"Immunology Letters","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; Arthritis Society; Northwestern University","keywords":"Haematopoiesis; Megakaryocyte; Progenitor cell; MHC class II; Major histocompatibility complex; Cell biology; MHC class I; Immunology; Biology; Stem cell; Cancer research; Antigen","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001493551,0.0001731234,0.0002405582,0.0002376387,0.0001132297,0.0002978057,0.0001140101,0.0001915834,0.002016871],"category_scores_gemma":[0.0001571254,0.0001699537,0.0001194726,0.0001500451,0.0001062305,0.00009542748,0.0002043716,0.0005159951,0.0005716995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007589412,"about_ca_system_score_gemma":0.00007226282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001061417,"about_ca_topic_score_gemma":0.0001830136,"domain_scores_codex":[0.9999137,0.00001724906,0.00001134079,0.00001367527,0.00002525204,0.00001878904],"domain_scores_gemma":[0.9999311,0.00001988713,0.0000107537,0.00001367941,0.000007629315,0.00001694692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004842769,0.00004764943,0.002749595,0.00004281533,0.0000143111,0.0003419136,0.00007510741,0.00007578982,0.989459,0.000350544,0.0003030422,0.006055921],"study_design_scores_gemma":[0.0001248165,0.0007294913,0.02918688,0.00001618137,0.00008218957,0.003629353,0.0001109201,0.001320695,0.9514703,0.0003296894,0.01298949,0.00001003504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947096,0.001117624,0.002222992,0.00005596089,0.00003876519,0.00004040965,0.0003940982,0.00006889362,0.001351552],"genre_scores_gemma":[0.9945084,0.0005919532,0.001544096,0.00004520904,0.00002129699,0.00004216623,0.0009771594,0.00002689733,0.002242719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002016871,"threshold_uncertainty_score":0.006747127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01271897912240975,"score_gpt":0.243878412269865,"score_spread":0.2311594331474553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}