{"id":"W2039234618","doi":"10.1186/1471-2377-8-11","title":"Reduction in magnetic resonance imaging T2 burden of disease in patients with relapsing-remitting multiple sclerosis: analysis of 48-week data from the EVIDENCE (EVidence of Interferon Dose-response: European North American Comparative Efficacy) study","year":2008,"lang":"en","type":"article","venue":"BMC Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Merck KGaA; Novartis Pharmaceuticals Corporation; Novartis; Pfizer","keywords":"Medicine; Tolerability; Multiple sclerosis; Internal medicine; Magnetic resonance imaging; Neurochemistry; Post-hoc analysis; Interferon beta-1a; Gastroenterology; Neurology; Nuclear medicine; Interferon beta; Surgery; Adverse effect; Immunology; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008951671,0.0008030024,0.002986203,0.001008213,0.0003395786,0.0008193959,0.0007099332,0.0007717072,0.001324684],"category_scores_gemma":[0.008600202,0.0003987584,0.002862883,0.0007677565,0.0005162489,0.000582459,0.00069559,0.001187446,0.0002067469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004296389,"about_ca_system_score_gemma":0.0003909142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003546102,"about_ca_topic_score_gemma":0.0006104137,"domain_scores_codex":[0.994054,0.00396351,0.000660601,0.0004873222,0.0006578048,0.0001767556],"domain_scores_gemma":[0.9873456,0.005805783,0.004341586,0.001094487,0.0006210518,0.0007913757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6788158,0.002606442,0.2550265,0.001854572,0.03099549,0.0001870103,0.0002999233,0.001091396,0.00376591,0.00004841968,0.000486552,0.02482196],"study_design_scores_gemma":[0.07963545,0.09574847,0.8037603,0.0001803715,0.01388826,0.000574195,0.0001476453,0.001829539,0.002038496,0.0001360316,0.001971283,0.0000899827],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949439,0.00374686,0.0002837487,0.0000514088,0.00001677905,0.0002156369,0.0004261464,0.00001136934,0.000304285],"genre_scores_gemma":[0.9979535,0.000435429,0.0004287257,0.00005153668,0.0000395029,0.0002072285,0.0007165129,0.000005650971,0.0001618134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008951671,"threshold_uncertainty_score":0.04734159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1749116616142978,"score_gpt":0.3431760205814864,"score_spread":0.1682643589671886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}