{"id":"W2039247139","doi":"10.1074/jbc.c113.502336","title":"TMPyP4 Porphyrin Distorts RNA G-quadruplex Structures of the Disease-associated r(GGGGCC)n Repeat of the C9orf72 Gene and Blocks Interaction of RNA-binding Proteins","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":221,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"RNA; Chemistry; RNA splicing; Nucleic acid; Gene; C9orf72; Biology; Molecular biology; Trinucleotide repeat expansion; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001906691,0.000112459,0.0003303945,0.00002281971,0.00004811211,0.000006280949,0.0002071873,0.0001145435,0.0001837862],"category_scores_gemma":[0.0008097104,0.00005260031,0.0002781479,0.0001225303,0.0003032404,0.00002383347,0.0001279838,0.0003558191,1.230749e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004190635,"about_ca_system_score_gemma":0.00009195607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001989157,"about_ca_topic_score_gemma":6.858472e-7,"domain_scores_codex":[0.9987741,0.00008286496,0.000499486,0.0001282158,0.0003715924,0.0001437992],"domain_scores_gemma":[0.9986373,0.00006873965,0.0007006315,0.0002316948,0.0002437928,0.000117824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001442636,0.0001520344,0.08028397,0.0001291723,0.0000995072,0.000006701562,0.00003659477,0.000006216963,0.9180338,0.000001427458,0.0001310918,0.00097519],"study_design_scores_gemma":[0.0005244248,0.000125356,0.3375099,0.0001662978,0.00006548357,0.00006271136,0.0001276654,0.00001521818,0.661156,0.0001519018,0.00005238888,0.00004263585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981822,0.0007435138,0.000007039607,0.0005244184,0.00005535129,0.0002832803,0.00001312417,0.000002575589,0.0001884934],"genre_scores_gemma":[0.9994691,0.0002029892,0.00005881477,0.00002692496,0.0000542514,0.000004142824,0.000003309144,0.000006755066,0.0001737406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.257226,"threshold_uncertainty_score":0.2144978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02296511353745377,"score_gpt":0.2715570883837078,"score_spread":0.2485919748462541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}