{"id":"W2039348718","doi":"10.1038/npp.2014.44","title":"Pharmacological Rescue of Cortical Synaptic and Network Potentiation in a Mouse Model for Fragile X Syndrome","year":2014,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China; National Science Foundation","keywords":"Long-term potentiation; Neuroscience; FMR1; Metabotropic glutamate receptor 5; NMDA receptor; Metabotropic glutamate receptor; Fragile X syndrome; Excitatory postsynaptic potential; Hippocampus; Glutamate receptor; Biology; Chemistry; Medicine; Internal medicine; Receptor; Psychiatry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001955045,0.0001432055,0.000203533,0.00005102885,0.00005124341,0.000005856951,0.0001345028,0.0001291998,0.00001296917],"category_scores_gemma":[0.00006229296,0.0001466789,0.00005159716,0.00007523377,0.0001037108,0.000002952347,0.00009068667,0.0001261532,0.000001542622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005243494,"about_ca_system_score_gemma":0.00002505639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000161171,"about_ca_topic_score_gemma":0.000007764715,"domain_scores_codex":[0.9987941,0.000141922,0.0002930729,0.0004002195,0.00007220054,0.0002985277],"domain_scores_gemma":[0.9996619,0.00003822446,0.00006492436,0.0001094369,0.00004191503,0.00008365306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0004438413,0.0001472814,0.001240624,0.00002406946,0.00003495007,0.000002510354,0.00001567711,0.02497454,0.9717897,0.00008159189,0.0006517606,0.0005934771],"study_design_scores_gemma":[0.01125278,0.00349665,0.1527153,0.00001498342,0.0001677851,0.00007303906,0.00001740178,0.764352,0.06382781,0.001129168,0.002222234,0.0007308748],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933903,0.0001207231,0.005547726,0.0002009573,0.0002349245,0.0004092811,0.00001400656,0.000008967227,0.00007307086],"genre_scores_gemma":[0.9967093,0.0003473615,0.001206421,0.001453151,0.00002796678,0.00008746391,0.00002342729,0.00002464082,0.000120296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9079618,"threshold_uncertainty_score":0.5981393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01172203629317917,"score_gpt":0.2703414610288572,"score_spread":0.258619424735678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}