{"id":"W2039373513","doi":"10.1016/j.bmcl.2014.04.005","title":"A chiral benzoylthiourea–pyrrolidine catalyst for the highly enantioselective Michael addition of ketones to chalcones","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Natural Science Foundation of China","keywords":"Pyrrolidine; Chemistry; Enantioselective synthesis; Catalysis; Michael reaction; Organic chemistry; Ketone; Enone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003831893,0.0005258507,0.00041289,0.0004927348,0.0003381649,0.0004772443,0.0007662964,0.0005328582,0.001708963],"category_scores_gemma":[0.0003176668,0.0002931237,0.0002016107,0.0003586108,0.0002997666,0.0003795564,0.0004398331,0.0007537208,0.001278989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008895429,"about_ca_system_score_gemma":0.0006038627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001622856,"about_ca_topic_score_gemma":0.002716785,"domain_scores_codex":[0.9997547,0.00003681576,0.00002470444,0.00003470025,0.00007273674,0.00007634727],"domain_scores_gemma":[0.9999155,0.00001268844,0.00001556537,0.00001055121,0.00001463705,0.00003103812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00047439,0.0002430441,0.0003628031,0.0003490565,0.00003773259,0.0008183353,0.0001379907,0.001012963,0.9587729,0.00283073,0.001949721,0.03301036],"study_design_scores_gemma":[0.0001306609,0.0005734799,0.001004109,0.00001837418,0.00004863794,0.0005071395,0.00002170742,0.004766991,0.982165,0.000242699,0.01048523,0.00003606861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.939299,0.004667605,0.0276791,0.0008476794,0.0005982171,0.0002097028,0.0004210442,0.0008661858,0.02541143],"genre_scores_gemma":[0.9905466,0.001355834,0.003455992,0.00006474848,0.00007013911,0.00002648357,0.0001974488,0.00005763909,0.004225106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001708963,"threshold_uncertainty_score":0.00645411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008438392186086045,"score_gpt":0.2139776427817342,"score_spread":0.2055392505956482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}