{"id":"W2039381596","doi":"10.1074/jbc.m113.473736","title":"The Adaptor Molecule Signaling Lymphocytic Activation Molecule (SLAM)-associated Protein (SAP) Is Essential in Mechanisms Involving the Fyn Tyrosine Kinase for Induction and Progression of Collagen-induced Arthritis","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"FYN; Autoimmunity; Tyrosine kinase; Bruton's tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; Cell biology; Biology; Immunology; Arthritis; Immune system; Signal transducing adaptor protein; Src family kinase; Signal transduction; Cancer research; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001325947,0.000501988,0.000241793,0.0002018485,0.0002586197,0.0003097751,0.0001585437,0.0003056244,0.0009258073],"category_scores_gemma":[0.0001183594,0.0001062071,0.0002748441,0.0001496762,0.0002216401,0.0002450723,0.0003478963,0.0005042011,0.0003965272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002514528,"about_ca_system_score_gemma":0.000268944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000368332,"about_ca_topic_score_gemma":0.0004118819,"domain_scores_codex":[0.9998168,0.00002918353,0.00001669192,0.00003022479,0.00004899997,0.00005811664],"domain_scores_gemma":[0.9998364,0.00001340943,0.00005782719,0.00001374422,0.00001732354,0.00006133082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008425188,0.00001296456,0.0003443394,0.00003703421,0.000003641381,0.0001012599,0.000008313958,0.00002443401,0.9979346,0.00009725209,0.00004429401,0.001307548],"study_design_scores_gemma":[0.00004031592,0.0005727308,0.03546605,0.00001874199,0.00003636305,0.001542496,0.00006215378,0.001536442,0.9499347,0.0001686332,0.01060963,0.00001188516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867572,0.005839048,0.004752827,0.0001411793,0.00007672064,0.00003783613,0.0005175669,0.0001597424,0.001717874],"genre_scores_gemma":[0.994536,0.001272426,0.001666598,0.00003936176,0.00001885136,0.00002726206,0.0004935656,0.00001067292,0.001935298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009258073,"threshold_uncertainty_score":0.003097117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01495195308917149,"score_gpt":0.236700343123765,"score_spread":0.2217483900345935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}