{"id":"W2039400815","doi":"10.3390/v7010180","title":"The Standard Scrapie Cell Assay: Development, Utility and Prospects","year":2015,"lang":"en","type":"review","venue":"Viruses","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Prion Research Institute","keywords":"Scrapie; Infectivity; Bioassay; Biology; Virology; In vitro; Prion protein; In vitro toxicology; Transmissible spongiform encephalopathy; Disease; Prion Proteins; Computational biology; Cell; Pathogenesis; Immunology; Medicine; Virus; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001964584,0.001080089,0.001923979,0.004095487,0.0003812127,0.001970721,0.001570098,0.001906506,0.002341087],"category_scores_gemma":[0.001376221,0.0006290915,0.0006968922,0.00292916,0.00118804,0.002562014,0.001054279,0.002430175,0.003584985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009901677,"about_ca_system_score_gemma":0.001350438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001369995,"about_ca_topic_score_gemma":0.001563471,"domain_scores_codex":[0.9992622,0.0001151378,0.00009216886,0.0001442842,0.0003355631,0.00005069846],"domain_scores_gemma":[0.9989905,0.0004003676,0.0001343629,0.00005496729,0.0003501851,0.00006958503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006665492,0.00007956547,0.0004388255,0.01362657,0.00005707858,0.0003086701,0.0001150796,0.0003767885,0.01305556,0.009818398,0.01832063,0.9437361],"study_design_scores_gemma":[0.00000534646,0.00009755355,0.0006547132,0.001363133,0.00005644125,0.001565174,0.00006948401,0.0001667514,0.005230732,0.002577312,0.9881728,0.00004054505],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003565956,0.9948505,0.001434801,0.0003773378,0.0002741627,0.00001700833,0.00006673009,0.00003299575,0.00258998],"genre_scores_gemma":[0.001549884,0.9946759,0.001725785,0.0002105562,0.0001445749,0.00002224482,0.000127513,0.000009167713,0.001534331],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004095487,"threshold_uncertainty_score":0.01038986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05697564411125534,"score_gpt":0.3366987127153377,"score_spread":0.2797230686040824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}