{"id":"W2039400815","doi":"10.3390/v7010180","title":"The Standard Scrapie Cell Assay: Development, Utility and Prospects","year":2015,"lang":"en","type":"review","venue":"Viruses","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Prion Research Institute","keywords":"Scrapie; Infectivity; Bioassay; Biology; Virology; In vitro; Prion protein; In vitro toxicology; Transmissible spongiform encephalopathy; Disease; Prion Proteins; Computational biology; Cell; Pathogenesis; Immunology; Medicine; Virus; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000631294,0.0002712778,0.0004121741,0.00002318449,0.0002243757,0.000114518,0.0002624719,0.0002058251,0.0000147885],"category_scores_gemma":[0.000136755,0.000173061,0.0001154192,0.00006940834,0.00009584032,0.000003020453,0.0003047564,0.0001271362,0.00001953216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002545683,"about_ca_system_score_gemma":0.0007790382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004356068,"about_ca_topic_score_gemma":0.00001006393,"domain_scores_codex":[0.9987722,0.0001473797,0.00027908,0.0003876974,0.0001698648,0.0002437848],"domain_scores_gemma":[0.9991812,0.00003281463,0.0001770322,0.0003966748,0.00007056055,0.0001417044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002096254,0.00001199968,0.00002111382,0.001157053,0.00006672904,0.000002068631,0.000005529485,1.826245e-8,0.00003787313,0.00001652779,0.004434719,0.9942254],"study_design_scores_gemma":[0.0001213338,0.0000456147,0.000004265113,0.0004103512,0.00008689179,0.000004125682,0.00000628389,2.03517e-7,0.0009104616,0.00006689146,0.998113,0.0002305629],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001256026,0.9985875,0.00004875052,0.000005781546,0.0001109735,0.000514723,0.0001124448,0.00001529628,0.0004789618],"genre_scores_gemma":[0.00008668919,0.998964,0.0002763442,0.0000643501,0.0001530443,0.00009089866,0.00007239328,0.00003312671,0.0002591435],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9939948,"threshold_uncertainty_score":0.7057222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05697564411125534,"score_gpt":0.3366987127153377,"score_spread":0.2797230686040824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}