{"id":"W2039402116","doi":"10.1016/j.chembiol.2011.02.013","title":"Rational Design of an Aryl-C-Glycoside Catalyst from a Natural Product O-Glycosyltransferase","year":2011,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Albert-Ludwigs-Universität Freiburg","keywords":"Glycosidic bond; Glycosyltransferase; Glycosylation; Mutant; Stereochemistry; Rational design; Biochemistry; Chemistry; Natural product; Glycoside hydrolase; Glycoside; Enzyme; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001468179,0.0003660787,0.0004764461,0.00002225147,0.00008648918,0.0000133624,0.0005728708,0.0003288042,0.005308683],"category_scores_gemma":[0.0002290975,0.0003524666,0.0001706809,0.0001231612,0.0003724097,0.0001209229,0.00006215619,0.0003423949,0.0000161518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006196005,"about_ca_system_score_gemma":0.0001793851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002521929,"about_ca_topic_score_gemma":0.000006969355,"domain_scores_codex":[0.9981188,0.00002962928,0.0005387911,0.0007731096,0.000144737,0.000394971],"domain_scores_gemma":[0.9984611,0.000188157,0.0001867514,0.0008454764,0.000136665,0.0001818636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00043385,0.0002683368,0.0007337693,0.0001192959,0.0001459827,0.00003319766,0.000292916,0.000006096555,0.9964412,0.00001210463,0.00007335833,0.001439891],"study_design_scores_gemma":[0.0004968517,0.00001646812,0.0001130825,0.00003548064,0.00008992806,0.00005508613,0.0001931697,0.0002487766,0.9974837,0.000646561,0.0002375405,0.0003834003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929779,0.0005643129,0.0001859455,0.00003685765,0.00009416242,0.00007342303,0.000422052,0.000111975,0.005533395],"genre_scores_gemma":[0.9957182,0.00003332193,0.001473555,0.00003057081,0.0004600722,0.00005482107,0.001787982,0.00003482459,0.0004066313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005292531,"threshold_uncertainty_score":0.9998927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0302547967635323,"score_gpt":0.2274944995987792,"score_spread":0.1972397028352469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}