{"id":"W2039406638","doi":"10.1021/ja0357588","title":"Diselenides and Allyl Selenides as Glutathione Peroxidase Mimetics. Remarkable Activity of Cyclic Seleninates Produced in Situ by the Oxidation of Allyl ω-Hydroxyalkyl Selenides","year":2003,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Organoselenium and organotellurium chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":253,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Chemistry; Selenide; Catalysis; Thiol; tert-Butyl hydroperoxide; Medicinal chemistry; Allyl alcohol; Organic chemistry; Selenium; Peroxidase; Catalytic cycle; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001391498,0.000308406,0.0007306808,0.00004388469,0.0001680352,0.00002335848,0.0005354257,0.0002371802,0.00008264459],"category_scores_gemma":[0.0009878034,0.0002098598,0.0003784348,0.0006918763,0.001464005,0.0001731917,0.0001413704,0.001217744,0.000001627199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001613707,"about_ca_system_score_gemma":0.0002623199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008651069,"about_ca_topic_score_gemma":0.000005195859,"domain_scores_codex":[0.9974968,0.0005366351,0.0008134154,0.0003065236,0.0004252923,0.0004212703],"domain_scores_gemma":[0.9967082,0.001037549,0.001526334,0.0002930623,0.0002621344,0.0001727254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003458855,0.0006358988,0.01610196,0.0001607614,0.0002628569,0.000001699017,0.001306841,0.00003844814,0.9775789,0.00001220011,0.002466262,0.00108833],"study_design_scores_gemma":[0.001101103,0.0001507552,0.002524187,0.00005290786,0.0002786196,0.0001009795,0.0006639223,0.00005255603,0.9933625,0.0002758819,0.001219832,0.000216716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958007,0.00136106,0.0000138441,0.002321766,0.00009774934,0.0002256859,0.00001565262,0.00001305272,0.000150508],"genre_scores_gemma":[0.996761,0.001878381,0.0006436397,0.0004419287,0.00009520589,0.000005639416,0.000002568712,0.00003272762,0.0001389511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01578368,"threshold_uncertainty_score":0.8557835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01851076242682536,"score_gpt":0.3267617625301977,"score_spread":0.3082510001033723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}