{"id":"W2039406638","doi":"10.1021/ja0357588","title":"Diselenides and Allyl Selenides as Glutathione Peroxidase Mimetics. Remarkable Activity of Cyclic Seleninates Produced in Situ by the Oxidation of Allyl ω-Hydroxyalkyl Selenides","year":2003,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Organoselenium and organotellurium chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":253,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Chemistry; Selenide; Catalysis; Thiol; tert-Butyl hydroperoxide; Medicinal chemistry; Allyl alcohol; Organic chemistry; Selenium; Peroxidase; Catalytic cycle; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001474044,0.0002930089,0.0001470935,0.0001349458,0.00004555347,0.0001414175,0.0001715477,0.0002367145,0.0005102163],"category_scores_gemma":[0.0001033816,0.00009104917,0.0001639439,0.0001362074,0.0001172516,0.0001899493,0.0001768927,0.000251187,0.0002007885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001266091,"about_ca_system_score_gemma":0.00007538654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001051857,"about_ca_topic_score_gemma":0.0002918035,"domain_scores_codex":[0.9999195,0.00002191948,0.000008588772,0.00001861017,0.00001675199,0.00001448549],"domain_scores_gemma":[0.999953,0.000007300752,0.00001323858,0.000005803109,0.000007572059,0.00001300654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005090791,0.000009737011,0.00005791995,0.00002980361,0.000004311195,0.00002628271,0.00001397812,0.00003887627,0.9984831,0.00007559937,0.00001613132,0.001193312],"study_design_scores_gemma":[0.000006652865,0.0002534891,0.0002409917,0.000001740139,0.000007382508,0.00006202806,0.000008410586,0.0001551564,0.9980228,0.00001835213,0.001221578,0.00000141333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915578,0.002799873,0.003786905,0.00008579007,0.00002494682,0.00003525245,0.0001200039,0.0000750776,0.00151427],"genre_scores_gemma":[0.9938952,0.001349167,0.002690144,0.00003047452,0.000006521838,0.00002068584,0.0001767745,0.00001134254,0.001819694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005102163,"threshold_uncertainty_score":0.001706839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01851076242682536,"score_gpt":0.3267617625301977,"score_spread":0.3082510001033723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}