{"id":"W2039468330","doi":"10.1074/jbc.m407085200","title":"Protein Kinase C Isoforms Differentially Phosphorylate Human Choline Acetyltransferase Regulating Its Catalytic Activity","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Robarts Clinical Trials","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Gene isoform; Phosphorylation; Cell biology; Choline acetyltransferase; Kinase; Protein kinase A; Biochemistry; MAP2K7; Chemistry; Biology; Cyclin-dependent kinase 2; Gene; Neuroscience; Cholinergic","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001529873,0.000249874,0.0001285791,0.0001733579,0.0001122368,0.0002434964,0.0001647697,0.0002370022,0.001059548],"category_scores_gemma":[0.0001790566,0.00006373037,0.0001979991,0.0002055383,0.0001307801,0.0001515571,0.0001314806,0.0002819674,0.0005247924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003541785,"about_ca_system_score_gemma":0.0002122238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001024725,"about_ca_topic_score_gemma":0.0009153193,"domain_scores_codex":[0.9998531,0.00001656521,0.00001394971,0.00003413879,0.00004411774,0.0000380363],"domain_scores_gemma":[0.9998866,0.00002020233,0.00003301001,0.00001207248,0.00002321111,0.00002477379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003268213,0.00003751635,0.001976978,0.00006585443,0.0000233189,0.000161884,0.0000274442,0.00007185557,0.9916232,0.0001998348,0.0001166474,0.005368622],"study_design_scores_gemma":[0.00006639591,0.0004357623,0.06416228,0.00002113045,0.000106767,0.002328802,0.00008236089,0.00115014,0.9216088,0.0003478421,0.009672829,0.00001684721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875562,0.007542475,0.001800882,0.0001832054,0.0000507777,0.00002591501,0.0003076581,0.00003608499,0.00249683],"genre_scores_gemma":[0.9891861,0.004382994,0.001866989,0.0001334288,0.00002992299,0.00003461594,0.0007594064,0.00001018103,0.003596264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001059548,"threshold_uncertainty_score":0.003544569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0209164278001521,"score_gpt":0.2513503381401044,"score_spread":0.2304339103399523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}